Abstract
WE cannot admit Dr. Michlin's claim to have been the first to show the non-identity of aldehyde mutase with aldehyde oxidase. It is well known from the work of Bernheim and others that the aldehydrase of the potato is a completely different enzyme from the aldehyde oxidase of animal tissues and milk (Schardinger enzyme). The fact that the potato aldehydrase has no mutase activity obviously does not show that the mutase and the Schardinger oxidase are distinct enzymes. Dr. Michlin indeed says in the paper referred to: βIt has not yet been possible, as far as we know, to separate the mutase from the aldehydrase or Schardinger enzyme, either in milk or in animal tissues or yeasts. Wieland's supposition, based on kinetic considerations, that the mutase and aldehydrase of milk are identical, has once again been established by Wieland and Macrae.β Dr. Michlin himself therefore evidently accepted the identification of the mutase with the Schardinger aldehyde oxidase. We have now separated these two enzymes and proved their non-identity.
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DIXON, M., LUTWAK-MANN, C. Aldehyde Mutase. Nature 139, 927 (1937). https://doi.org/10.1038/139927a0
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DOI: https://doi.org/10.1038/139927a0
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