Abstract
WHILE determining the vitamin C content of urine taken from healthy individuals or patients suffering from various diseases by titration with 2–6 dichlorophenolindophenol, we tried to perform this test in the living organism itself. First we injected small quantities of a 1/1,000 normal sterile solution of the dye into the sole of healthy and scorbutic guinea pigs. We observed that decoloration of the dye takes place much more rapidly in healthy animals than in guinea pigs suffering from scurvy. When methyl blue was injected simultaneously, its colour remained unchanged, which shows that decoloration of dichlorophenolindophenol was not due to resorption but to reduction.
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ROTTER, H. Determination of Vitamin C in the Living Organism. Nature 139, 717 (1937). https://doi.org/10.1038/139717a0
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DOI: https://doi.org/10.1038/139717a0
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Zeitschrift für Untersuchung der Lebensmittel (1938)
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