Abstract
MY colleagues and I have been developing recently the theory that vitamin B1 is a specific factor in the oxidation system of pyruvic acid. In a search for substances which would inhibit specifically this action of vitamin B1 in its relation to the pyruvate oxidase of brain, I tried ten months ago the effect of dichlor-diethyl-sulphone (Cl.CH2.CH2)2 S.O2, for a specimen of which I am indebted to Dr. E. Walker. I am encouraged to communicate the results by the recent publication of Berenblum, Kendall and Orr1, who state that D.E.S. with tumour tissue inhibits respiration some 50 per cent and glycolysis some 84 per cent. I have found that the action of D.E.S. upon our brain respiration systems in vitro resembles in detail the effect of iodoacetic acid2; the significant points are as follow:
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References
Berenblum, Kendall and Orr, Biochem J., 30, 709 (1936).
Peters, Rydin and Thompson, ibid., 29, 53 (1935)
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PETERS, R. Effect of Dichlor-diethyl-sulphone on Brain Respiration. Nature 138, 327–328 (1936). https://doi.org/10.1038/138327b0
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DOI: https://doi.org/10.1038/138327b0
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