Abstract
The effect of age on plasma felbamate (F) clearance was examined through a retrospective analysis of concentration data from pediatric and adult epileptic patients in six clinical studies. Patients received F either as monotherapy (MONO), or in combination with either carbamazepine (F+C), valproate (F+V) or phenytoin (F+P). A total of 3345 evaluable F concentration values were available from 700 patients aged between 2 and 74 years. These were analyzed using a non-linear mixed effect pharmacostatistical modeling technique (NONMEM). Factors in the model included age, body weight, and concomitant AED. A comparison of 2-12 yr and 13-65 yr age groups is given below.
F clearance, as calculated by NONMEM, was higher in young compared with adult patients across all groups, and the magnitude of this difference was similar (40%). The magnitude of the enzyme-inducing effect of C and P on F clearance was similar in children and adults.
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Banfield, C., Zhu, G., Jen, F. et al. Population Pharmacokinetics of Felbamate - Effect of Age on Apparent Clearance. Neuropsychopharmacol 11, 270 (1994). https://doi.org/10.1038/sj.npp.1380153
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DOI: https://doi.org/10.1038/sj.npp.1380153