Abstract
RECENT work on endocrines has brought out two facts interesting in their implications. One is that pregnancy urine, blood serum and placental extracts produce lutein cells in the hypophysectomised animal but do not induce follicular growth1,2,3; and the other is the discovery4 of an activation factor in adult beef hypophysis which is not identical with either the growth or maturity hormones. Since it is well known that these pregnancy extracts will induce precocious sexual maturity in normal immature animals (in other words, follicular growth), it seems certain that they contain an activation factor which stimulates the hypophysis of the host, thus initiating growth in the ovary. There is as yet no basis for comparing these two factors, but, since the hypophysis of the pregnant rat shows but little increase in potency over that of the non-pregnant one5, this organ would not seem to be responsible for the activator in pregnancy extracts, this probably coming from the placenta.
Similar content being viewed by others
Article PDF
References
Noguchi, Jap. J. Med. Sci. Pharm., 5, 104; 1931.
Collip, Selye and Thomson, NATURE, 131, 56, Jan. 14, 1933.
Leonard and Smith, Proc. Soc. Exp. Biol Med., 30, 1248; 1933.
Evans, Simpson and Austin, J. Exp. Med., 57, 897; 1933.
Evans and Simpson, Amer. J. Physiol., 89, 579; 1929.
Swezy, “Ovogenesis and the Hypophysis”, Science Press; 1933.
Smith and Engle, Amer. J. Anat., 40, 277; 1927.
Lipschütz, Endokrin., 13, 90; 1933.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SWEZY, O. Lack of Maturity Hormone in the Hypophysis of the Infantile Rat. Nature 132, 898 (1933). https://doi.org/10.1038/132898a0
Issue Date:
DOI: https://doi.org/10.1038/132898a0
This article is cited by
-
Malignant growth in relation to enzyme activity
Protoplasma (1935)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.