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The field of cancer research: an indicator of present transformations in biology

Oncogene volume 26, pages 7607–7610 (2007)Cite this article

Abstract

‘Biology and cancer research have developed together. Invariably, at each stage, the characteristics of the cancer cell have been ascribed to some defect in whatever branch of biology happens at the time to be fashionable and exciting; today, it is molecular genetics’. Tremendous transformations have occurred in cancer research since these few lines were written by John Cairns: the discovery of oncogenes and anti-oncogenes, and the successful development of ‘magic bullets’ targeting the proteins encoded by these oncogenes. Nevertheless, Cairns’ message is still valid. In 1978, he observed the first attempts to apply the tools and concepts of molecular biology to cancer; today, this research field reflects multiple and diverse efforts that go ‘beyond’ molecular biology by looking for explanations that have been left aside during its development, or by privileging new approaches, fully original or actively pursued in other fields of biological research. Because of this specific characteristic of cancer research, it is possible to use it as an indicator of trends in biological research in general.

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References

  • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB et al. (2006). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756–760.

    Article  CAS  Google Scholar 

  • Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. (2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444: 633–642.

    Article  CAS  Google Scholar 

  • Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D et al. (2006). Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439: 353–357.

    Article  CAS  Google Scholar 

  • Bissell MJ, Radisky D . (2001). Putting tumours in context. Nat Rev Cancer 1: 46–54.

    Article  CAS  Google Scholar 

  • Borczuk AC, Cappellini GCA, Kim HK, Hesdorffer M, Taub RN, Powell CA . (2007). Molecular profiling of malignant peritoneal mesothelioma identifies the ubiquitin-proteasome pathway as a therapeutic target in poor prognosis tumors. Oncogene 26: 610–617.

    Article  CAS  Google Scholar 

  • Cairns J . (1978). Cancer, Science, and Society. Freeman: San Francisco, p 63.

    Google Scholar 

  • Downward J . (2006). Prelude to an anniversary for the RAS oncogene. Science 314: 43–44.

    Article  Google Scholar 

  • Feinberg AP, Tycko B . (2004). The history of cancer epigenetics. Nat Rev Cancer 4: 143–153.

    Article  CAS  Google Scholar 

  • Ferres-Marco D, Gutierrez-Garcia I, Vallejo DM, Bolivar J, Gutierrez-Avino FJ, Dominguez M . (2006). Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439: 430–436.

    Article  CAS  Google Scholar 

  • Frantz S . (2005). Playing dirty. Nature 437: 942–943.

    Article  CAS  Google Scholar 

  • Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G et al. (2007). Patterns of somatic mutation in human cancer genomes. Nature 446: 153–158.

    Article  CAS  Google Scholar 

  • Hanahan D, Weinberg RA . (2000). The hallmarks of cancer. Cell 100: 57–70.

    Article  CAS  Google Scholar 

  • Hiratsuka S, Watanabe A, Aburatani H, Maru Y . (2006). Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat cell biol 8: 1369–1375.

    Article  CAS  Google Scholar 

  • Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC et al. (2003). A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425: 407–410.

    Article  CAS  Google Scholar 

  • Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C et al. (2005). VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438: 820–827.

    Article  CAS  Google Scholar 

  • Kerbel RS . (2006). Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 312: 1171–1175.

    Article  CAS  Google Scholar 

  • Kiberstis PA, Travis J . (2006). Celebrating a glass half-full. Science 312: 1157.

    Article  CAS  Google Scholar 

  • Kinzler KW, Vogelstein B . (1996). Lessons from hereditary colorectal cancer. Cell 87: 159–170.

    Article  CAS  Google Scholar 

  • Lund AH, van Lohuizen M . (2004). Epigenesis and cancer. Genes Dev 18: 2315–2335.

    Article  CAS  Google Scholar 

  • Manchester KL . (1995). Theodor Boveri and the origin of malignant tumours. Trends Cell Biol 5: 384–387.

    Article  CAS  Google Scholar 

  • Marx J . (2003). Mutant stem cells may seed cancer. Science 301: 1308–1310.

    Article  CAS  Google Scholar 

  • Marx J . (2006). Autophagy: is it cancer's friend or foe? Science 312: 1160–1161.

    Article  CAS  Google Scholar 

  • Morange M . (1997). From the regulatory vision of cancer to the oncogene paradigm, 1975–1985. J Hist Biol 30: 1–29.

    Article  CAS  Google Scholar 

  • Morange M . (2006). Twenty-five years ago: the production of mouse embryonic stem cells. J Biosci 31: 537–541.

    Article  Google Scholar 

  • O'Brien CA, Pollett A, Gallinger S, Dick JE . 2007. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106–110.

    Article  CAS  Google Scholar 

  • Odling-Smee FJ, Laland KN, Feldman MW . (2003). Niche Construction: The Neglected Process in Evolution. Princeton University Press: Princeton.

    Google Scholar 

  • Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KCQ, Navin N et al. (2006). Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc Natl Acad Sci USA 103: 19848–19853.

    Article  CAS  Google Scholar 

  • Piccirillo SGM, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G et al. (2006). Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761–765.

    Article  CAS  Google Scholar 

  • Ramanathan A, Wang C, Schreiber SL . (2005). Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci USA 102: 5992–5997.

    Article  CAS  Google Scholar 

  • Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C et al. 2007. Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111–115.

    Article  CAS  Google Scholar 

  • Soto AM, Sonnenschein C . (2004). The somatic mutation theory of cancer: growing problems with the paradigm? BioEssays 26: 1097–1107.

    Article  CAS  Google Scholar 

  • Triolo VA . (1965). Nineteenth century foundations of cancer research: advances in tumor pathology, nomenclature, and theories of oncogenesis. Cancer Res 25: 75–106.

    CAS  PubMed  Google Scholar 

  • Valk-Lingbeek ME, Bruggeman SWM, van Lohuizen M . (2004). Stem cells and cancer: the polycomb connection. Cell 118: 409–418.

    Article  CAS  Google Scholar 

  • Waddington CH . (1941). Canalization of development and the inheritance of acquired characteristics. Nature 150: 563–565.

    Article  Google Scholar 

  • Warburg O . (1956). On the origin of cancer cells. Science 123: 309–314.

    Article  CAS  Google Scholar 

  • Weaver BA, Cleveland DW . (2006). Does aneuploidy cause cancer? Curr Opin Cell Biol 18: 658–667.

    Article  CAS  Google Scholar 

  • Weinberg RA . (1982). Fewer and fewer oncogenes. Cell 30: 3–4.

    Article  CAS  Google Scholar 

Download references

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  1. Département de biologie, Ens, Paris Cedex, France

    M Morange

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Correspondence to M Morange.

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Morange, M. The field of cancer research: an indicator of present transformations in biology. Oncogene 26, 7607–7610 (2007). https://doi.org/10.1038/sj.onc.1210583

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