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Translational regulation by the p210 BCR/ABL oncoprotein

Oncogene volume 23, pages 3222–3229 (2004)Cite this article

Abstract

The ability of oncogenic proteins to regulate the rate of translation of specific mRNA subsets may be a rapid and efficient mechanism to modulate the levels and, in many cases, the activity of the corresponding proteins. In the past few years, we have identified several RNA binding proteins with translation regulatory activity whose expression is markedly activated in the blast crisis of chronic myelogenous leukemia, which represents the most malignant disease stage. Perturbation of the activity of some RNA binding proteins suppresses the leukemogenic potential of BCR/ABL-expressing cells. Most importantly, we have identified some of the targets of these RNA binding proteins. Two of these targets, c/ebpα and mdm2 mRNAs, are directly relevant for the altered differentiation and survival of leukemic cells. The identification of mRNA targets translationally regulated by RNA binding proteins overexpressed in tumor cells may lead to the development of therapeutic strategies aimed at modulating the translation rate of specific mRNAs.

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Acknowledgements

We thank Kristin Becknell and Catherine Tomastik for editorial assistance. This work is supported in part by the National Cancer Institute P30 CA16058, by NIH Grants to DP (1R01 CA095512-01A2) and BC (PO1 CA78890) and by a Department of the Army CMLRP (DAMD17-03-1-0184) grant to DP The support of the Elsa U Pardee and the Lauri Strauss Leukemia Foundation is also gratefully acknowledged.

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  1. Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA

    Danilo Perrotti

  2. Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA

    Bruno Calabretta

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Correspondence to Danilo Perrotti.

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Perrotti, D., Calabretta, B. Translational regulation by the p210 BCR/ABL oncoprotein. Oncogene 23, 3222–3229 (2004). https://doi.org/10.1038/sj.onc.1207543

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