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The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

Oncogene volume 23, pages 2028–2036 (2004)Cite this article

Abstract

Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCFβ-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFβ-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting β-TrCP as a means of anticancer therapy are also discussed.

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Acknowledgements

Support from the NCI Grant CA 92900 (to SYF) and American Cancer Society award RSG-02-140-01-CNE (to VSS) is gratefully acknowledged.

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  1. Department of Animal Biology, University of Pennsylvania, Rm 161E, 3800 Spruce Street, Philadelphia, 19104, PA, USA

    Serge Y Fuchs & K G Suresh Kumar

  2. AMC Cancer Research Center, Lakewood, 80214, CO, USA

    Vladimir S Spiegelman

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  1. Serge Y Fuchs
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  2. Vladimir S Spiegelman
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Correspondence to Serge Y Fuchs.

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Fuchs, S., Spiegelman, V. & Suresh Kumar, K. The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028–2036 (2004). https://doi.org/10.1038/sj.onc.1207389

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