Abstract
Members of the TRP superfamily of cation channels have homeostatic and regulatory functions in cells and changes in their expression may contribute to malignant growth. Previously, we have demonstrated that the gene of the Ca2+-selective cation channel CaT-L or TRPV6 is not expressed in benign prostate tissues including benign prostate hyperplasia, but is upregulated in prostate cancer. Here, we report on the differential expression of TRPV6 mRNA in prostate tissue obtained from 140 patients with prostate cancer. Using in situ hybridization, TRPV6 transcripts were undetectable in benign prostate tissue, high-grade prostatic intraepithelial neoplasia (n=57), incidental adenocarcinoma and all tumors less than 2.3 cubic centimeter (cc). In prostatectomy specimens from 97 clinically organ-confined tumors, TRPV6 expression correlated significantly with the Gleason score (P=0.032), pathological stage (P<0.001) and extraprostatic extension (P=0.025). Lymph node metastasis (n=17) and androgen-insensitive tumors (n=27) revealed TRPV6 expression in 63 and 67% of cases, respectively. The latter, however, revealed markedly and significantly decreased levels when compared with untreated tumors (P=0.044). In summary, the data demonstrate that TRPV6 expression is associated with prostate cancer progression. Accordingly, TRPV6 represents a prognostic marker and, as a plasma membrane Ca2+ channel, a promising target for new therapeutic strategies to treat advanced prostate cancer.
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References
Bonkhoff H, Fixemer T, Hunsicker I and Remberger K . (1999). Am. J. Pathol., 155, 641–647.
Cupp MR, Bostwick DG, Myers RP and Oesterling JE . (1995). J. Urol., 153, 1543–1548.
Hoenderop JGJ, Vennekens R, Müller D, Prenen J, Droogmans G, Bindels RJM and Nilius B . (2001). J. Physiol., 537, 747–761.
Mariot P, Vanoverberghe K, Lalevée N, Rossier MF and Prevarskaya N . (2002). J. Biol. Chem., 277, 10824–10833.
Narayan P, Gajendran V, Taylor SP, Tewari A, Presti Jr JC, Leidich R, Lo R, Palmer K, Shinohara K and Spaulding JT . (1995). Urology, 46, 205–212.
Niemeyer BA, Bergs C, Wissenbach U, Flockerzi V and Trost C . (2001). Proc. Natl. Acad. Sci. USA, 98, 3600–3605.
Partin AW, Kattan MW, Subong EN, Walsh PC, Wojno KJ, Oesterling JE, Scardino PT and Pearson JD . (1997). JAMA, 14, 1445–1451.
Peng J-B, Chen X-Z, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM and Hediger MA . (1999). J. Biol. Chem., 274, 22739–22746.
Steinberg DM, Sauvageot J, Piantadosi S and Epstein JI . (1997). Am. J. Surg. Pathol., 21, 566–576.
Toyota M, Ho C, Ohe-Toyota M, Baylin SB and Issa J-PJ . (1999). Cancer Res., 59, 4535–4541.
Wills ML, Sauvageot J, Partin AW, Gurganus R and Epstein JI . (1998). Urology, 51, 759–764.
Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalié A, Reus K, Meese E, Bonkhoff H and Flockerzi V . (2001). J. Biol. Chem., 276, 19461–19468.
Acknowledgements
This work was supported, in part, by the Fonds der Chemischen Industrie, Wilhelm Sander-Stiftung and Landesforschungsförderungsprogramm 0113.
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Fixemer, T., Wissenbach, U., Flockerzi, V. et al. Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22, 7858–7861 (2003). https://doi.org/10.1038/sj.onc.1206895
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DOI: https://doi.org/10.1038/sj.onc.1206895
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