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  • Original Paper
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Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1

Oncogene volume 22, pages 6166–6176 (2003)Cite this article

Abstract

Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies.

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Acknowledgements

This work was supported by grants to George Blanck from the National Institutes of Health (R01-CA81497) and the American Cancer Society (RPG-98-184-01-CIM). We thank Edward M Haller for expert technical assistance with the electron microscopy analyses; Jodi Kroeger and Johana Melendez for expert technical assistance at the Moffitt Flow Cytometry core facility; and Kimberly M Palubin for help with mouse genotyping.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, 33612, FL, USA

    Donna D Eason, Cynthia LeBron & George Blanck

  2. Department of Pathology, College of Medicine, University of South Florida, Tampa, 33612, FL, USA

    Domenico Coppola, Lynn C Moscinski, Sandra Livingston & George Blanck

  3. Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa, 33612, FL, USA

    E Truitt Sutton

  4. Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, 33612, FL, USA

    Domenico Coppola, Lynn C Moscinski & George Blanck

  5. Department of Environmental and Occupational Health, College of Public Health, University of South Florida, Tampa, 33612, FL, USA

    E Truitt Sutton

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  1. Donna D Eason
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Correspondence to George Blanck.

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Eason, D., LeBron, C., Coppola, D. et al. Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1. Oncogene 22, 6166–6176 (2003). https://doi.org/10.1038/sj.onc.1206563

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