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DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway

Oncogene volume 20, pages 6960–6964 (2001)Cite this article

Abstract

DOC-2/hDab-2 was identified due to the loss of its expression in primary ovarian cancer cells. It is believed that loss of DOC-2/hDab-2 expression is one of the early events of ovarian malignancy. These results suggest a function of DOC-2/hDab-2 as a tumor suppressor. However, it is not clear how DOC-2/hDab-2 negatively regulates cancer cell growth. In this report, we demonstrate that DOC-2/hDab-2 expression in breast cancer cells resulted in sensitivity to suspension-induced cell death (anoikis). This event was associated with the down-regulation of the integrin-linked kinase (ILK) activity. Since ILK is a key factor in regulating the cellular signaling in responding to the extracellular signals through adhesion molecules like integrins, our results indicate that DOC-2/hDab-2 may prevent tumor growth and invasion by modulating the anti-apoptotic ILK pathway.

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Author notes

  1. Shao-Chun Wang and Keishi Makino: These two authors contributed equally

Authors and Affiliations

  1. Department of Molecular and Cellular Oncology, The University of Texas, M.D. Anderson Cancer Center, Texas, Houston, USA

    Shao-Chun Wang, Keishi Makino, Weiya Xia, Jeong Soo Kim, Hua Peng & Mien-Chie Hung

  2. Department of Neuro-Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA

    Seock-Ah Im

  3. Department of Surgical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA

    Sonja E Singletary

  4. Division of Gynecologic Oncology, Laboratory of Gynecologic Oncology, Brigham and Women's Hospital, Dana Farber Harvard Cancer Center, Houston, Texas, USA

    Samuel C Mok

  5. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Dana Farber Harvard Cancer Center, Houston, Texas, USA

    Samuel C Mok

Authors
  1. Shao-Chun Wang
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  2. Keishi Makino
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  3. Weiya Xia
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  7. Samuel C Mok
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  9. Mien-Chie Hung
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Correspondence to Mien-Chie Hung.

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Wang, SC., Makino, K., Xia, W. et al. DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway. Oncogene 20, 6960–6964 (2001). https://doi.org/10.1038/sj.onc.1204873

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  • DOI: https://doi.org/10.1038/sj.onc.1204873

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