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PML interaction with p53 and its role in apoptosis and replicative senescence

Oncogene volume 20, pages 7250–7256 (2001)Cite this article

Abstract

A network of control pathways has been characterized that arrest growth or induce apoptosis in response to potentially tumorogenic events such as genotoxic stress or oncogene expression. Ablation, or functional disruption, of these pathways is frequently observed during multistep carcinogenesis. Analysis of those genes most commonly compromized in tumours has led to the identification of the transcription factor p53 and the E2F binding protein Retinoblastoma (Rb), as key regulators of these processes. This review discusses recent data, demonstrating that the Promyelocytic Leukemia (PML) protein can physically and functionally interact with both p53 and Rb, suggesting that PML may be a novel regulator of these pathways.

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References

  • Adler V, Schaffer A, Kim J, Dolan L, Ronai Z . 1995 J. Biol. Chem. 270: 26071–26077

  • Ahn JH, Hayward GS . 1997 J. Virol. 71: 4599–4613

  • Ahn JH, Hayward GS . 2000 Virology 274: 39–55

  • Alcalay M, Tomassoni L, Colombo E, Stoldt S, Grignani F, Fagioli M, Szekely L, Helin K, Pelicci PG . 1998 Mol. Cell. Biol. 18: 1084–1093

  • Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC . 1996 Proc. Natl. Acad. Sci. USA 93: 13742–13747

  • Appella E, Anderson CW . 2000 Pathol. Biol. (Paris) 48: 227–245

  • Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K . 1995 Proc. Natl. Acad. Sci. USA 92: 8348–8352

  • Bernstam L, Nriagu J . 2000 J. Toxicol. Environ. Health B. Crit. Rev. 3: 293–322

  • Bischof O, Kim SH, Irving J, Beresten S, Ellis NA, Campisi J . 2001 J. Cell. Biol. 153: 367–380

  • Boisvert FM, Kruhlak MJ, Box AK, Hendzel MJ, Bazett-Jones DP . 2001 J. Cell. Biol. 152: 1099–1106

  • Brown JP, Wei W, Sedivy JM . 1997 Science 277: 831–834

  • Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR . 1997 Nat. Med. 3: 1271–1274

  • Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR . 1995 EMBO J. 14: 4240–4248

  • Chang HY, Nishitoh H, Yang X, Ichijo H, Baltimore D . 1998 Science 281: 1860–1863

  • Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD . 1999 Proc. Natl. Acad. Sci. USA 96: 13777–13782

  • Chelbi-Alix MK, Pelicano L, Quignon F, Koken MH, Venturini L, Stadler M, Pavlovic J, Degos L, de The H . 1995 Leukemia 9: 2027–2033

  • Cooke HJ, Smith BA . 1986 Cold Spring Harb. Symp. Quant. Biol. 51: 213–219

  • Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S . 1992 EMBO J. 11: 1921–1929

  • Davis RJ . 2000 Cell 103: 239–252

  • Doucas V, Tini M, Egan DA, Evans RM . 1999 Proc. Natl. Acad. Sci. USA 96: 2627–2632

  • Dyck JA, Maul GG, Miller Jr WH, Chen JD, Kakizuka A, Evans RM . 1994 Cell 76: 333–343

  • Enari M, Talanian RV, Wong WW, Nagata S . 1996 Nature 380: 723–726

  • Everett RD, Lomonte P, Sternsdorf T, van Driel R, Orr A . 1999 J. Cell. Sci. 112: 4581–4588

  • Everett RD, Maul GG . 1994 EMBO J. 13: 5062–5069

  • Fagioli M, Alcalay M, Tomassoni L, Ferrucci PF, Mencarelli A, Riganelli D, Grignani F, Pozzan T, Nicoletti I, Pelicci PG . 1998 Oncogene 16: 2905–2913

  • Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW . 2000 Genes Dev. 14: 2015–2027

  • Fernandes-Alnemri T, Litwack G, Alnemri ES . 1994 J. Biol. Chem. 269: 30761–30764

  • Fogal V, Gostissa M, Sandy P, Zacchi P, Sternsdorf T, Jensen K, Pandolfi PP, Will H, Schneider C, Del Sal G . 2000 EMBO J. 19: 6185–6195

  • Giaccia AJ, Kastan MB . 1998 Genes Dev. 12: 2973–2983

  • Gostissa M, Hengstermann A, Fogal V, Sandy P, Schwarz SE, Scheffner M, Del Sal G . 1999 EMBO J. 18: 6462–6471

  • Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA . 1998 Oncogene 16: 1723–1730

  • Grignani F, Testa U, Rogaia D, Ferrucci PF, Samoggia P, Pinto A, Aldinucci D, Gelmetti V, Fagioli M, Alcalay M, Seeler J, Nicoletti I, Peschle C, Pelicci PG . 1996 EMBO J. 15: 4949–4958

  • Grobelny JV, Godwin AK, Broccoli D . 2000 J. Cell. Sci. 113 Pt 24 4577–4585

  • Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Paolo Pandolfi P . 2000 Nat. Cell. Biol. 2: 730–736

  • Harvey M, Sands AT, Weiss RS, Hegi ME, Wiseman RW, Pantazis P, Giovanella BC, Tainsky MA, Bradley A, Donehower LA . 1993 Oncogene 8: 2457–2467

  • Haupt Y, Maya R, Kazaz A, Oren M . 1997 Nature 387: 296–299

  • Hayflick L, Moorhead PS . 1961 Exper. Cell. Res. 25: 585–621

  • Hodges M, Tissot C, Howe K, Grimwade D, Freemont PS . 1998 Am. J. Hum. Genet. 63: 297–304

  • Inoue K, Wen R, Rehg JE, Adachi M, Cleveland JL, Roussel MF, Sherr CJ . 2000 Genes Dev. 14: 1797–1809

  • Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss III JF, Maul GG . 1999 J. Cell. Biol. 147: 221–234

  • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M . 1999 Nature 397: 164–168

  • Jiang WQ, Ringertz N . 1997 Cell Growth Differ. 8: 513–522

  • Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ . 1997 Cell 91: 649–659

  • Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ . 1998 Nature 396: 84–88

  • Ko LJ, Prives C . 1996 Genes Dev. 10: 1054–1072

  • Kolesnick R, Hannun YA . 1999 Trends Biochem. Sci. 24: 224–225 discussion 227

  • Kubbutat MH, Jones SN, Vousden KH . 1997 Nature 387: 299–303

  • Lambert PF, Kashanchi F, Radonovich MF, Shiekhattar R, Brady JN . 1998 J. Biol. Chem. 273: 33048–33053

  • LaMorte VJ, Dyck JA, Ochs RL, Evans RM . 1998 Proc. Natl. Acad. Sci. USA 95: 4991–4996

  • Lansdorp PM, Poon S, Chavez E, Dragowska V, Zijlmans M, Bryan T, Reddel R, Egholm M, Bacchetti S, Martens U . 1997 Ciba. Found Symp. 211: 209–218

  • Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC . 1995 Proc. Natl. Acad. Sci. USA 92: 9042–9046

  • Le S, Moore JK, Haber JE, Greider CW . 1999 Genetics 152: 143–152

  • Le XF, Vallian S, Mu ZM, Hung MC, Chang KS . 1998 Oncogene 16: 1839–1849

  • Le XF, Yang P, Chang KS . 1996 J. Biol. Chem. 271: 130–135

  • Liu JH, Mu ZM, Chang KS . 1995 J. Exp. Med. 181: 1965–1973

  • Liu X, Zou H, Slaughter C, Wang X . 1997 Cell 89: 175–184

  • Lombard DB, Guarente L . 2000 Cancer Res. 60: 2331–2334

  • Longo L, Trecca D, Biondi A, Lo Coco F, Grignani F, Maiolo AT, Pelicci PG, Neri A . 1993 Leuk. Lymphoma 11: 405–410

  • Lundblad V, Blackburn EH . 1993 Cell 73: 347–360

  • Martin-Rivera L, Herrera E, Albar JP, Blasco MA . 1998 Proc. Natl. Acad. Sci. USA 95: 10471–10476

  • Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T . 2000 EMBO J. 19: 662–671

  • Maul GG, Ishov AM, Everett RD . 1996 Virology 217: 67–75

  • Maul GG, Yu E, Ishov AM, Epstein AL . 1995 J. Cell. Biochem. 59: 498–513

  • Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA . 1997 Cell 90: 785–795

  • Michaelson JS, Bader D, Kuo F, Kozak C, Leder P . 1999 Genes Dev. 13: 1918–1923

  • Mu ZM, Chin KV, Liu JH, Lozano G, Chang KS . 1994 Mol. Cell. Biol. 14: 6858–6867

  • Muller H, Helin K . 2000 Biochim. Biophys. Acta. 1470: M1–M12

  • Muller S, Matunis MJ, Dejean A . 1998 EMBO J. 17: 61–70

  • Nagata S, Golstein P . 1995 Science 267: 1449–1456

  • Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR . 1997 Science 277: 955–959

  • Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, Higashimoto Y, Appella E, Minucci S, Pandolfi PP, Pelicci PG . 2000 Nature 406: 207–210

  • Pelletier G, Stefanovsky VY, Faubladier M, Hirschler-Laszkiewicz II, Savard J, Rothblum LI, Cote J, Moss T . 2000 Mol. Cell. 6: 1059–1066

  • Pluta AF, Earnshaw WC, Goldberg IG . 1998 J. Cell. Sci. 111: 2029–2041

  • Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA . 1998 Cell 92: 713–723

  • Regad T, Saib A, Lallemand-Breitenbach V, Pandolfi PP, de The H, Chelbi-Alix MK . 2001 EMBO J. 20: 3495–3505

  • Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A . 2001 EMBO J. 20: 2140–2151

  • Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E . 1998 Genes Dev. 12: 2831–2841

  • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW . 1997 Cell 88: 593–602

  • Shay JW, Pereira-Smith OM, Wright WE . 1991 Exp. Cell. Res. 196: 33–39

  • Strasser A, Harris AW, Jacks T, Cory S . 1994 Cell 79: 329–339

  • Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM . 1995 Cell 81: 801–809

  • Torii S, Egan DA, Evans RA, Reed JC . 1999 EMBO J. 18: 6037–6049

  • Vallian S, Chin KV, Chang KS . 1998a Mol. Cell. Biol. 18: 7147–7156

  • Vallian S, Gaken JA, Gingold EB, Kouzarides T, Chang KS, Farzaneh F . 1998b Oncogene 16: 2843–2853

  • von Mikecz A, Zhang S, Montminy M, Tan EM, Hemmerich P . 2000 J. Cell. Biol. 150: 265–273

  • Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C, Grosveld F, Pandolfi PP . 1998a Science 279: 1547–1551

  • Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP . 1998b Nat. Genet. 20: 266–272

  • Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M, Lamond A, Dejean A . 1994 Cell 76: 345–356

  • Wu G, Lee WH, Chen PL . 2000 J. Biol. Chem. 275: 30618–30622

  • Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS . 2001 Mol. Cell. Biol. 21: 2259–2268

  • Yang X, Khosravi-Far R, Chang HY, Baltimore D . 1997 Cell 89: 1067–1076

  • Yeager TR, Neumann AA, Englezou A, Huschtscha LI, Noble JR, Reddel RR . 1999 Cancer Res. 59: 4175–4179

  • Zhang Y, Xiong Y, Yarbrough WG . 1998 Cell 92: 725–734

  • Zheng P, Guo Y, Niu Q, Levy DE, Dyck JA, Lu S, Sheiman LA, Liu Y . 1998 Nature 396: 373–376

  • Zhong S, Muller S, Ronchetti S, Freemont PS, Dejean A, Pandolfi PP . 2000 Blood 95: 2748–2752

  • Zhu J, Koken MH, Quignon F, Chelbi-Alix MK, Degos L, Wang ZY, Chen Z, de The H . 1997 Proc. Natl. Acad. Sci. USA 94: 3978–3983

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  1. Department of Experimental Oncology, European Institute of Oncology, Milano, 20141, Italy

    Mark Pearson & Pier Giuseppe Pelicci

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Correspondence to Pier Giuseppe Pelicci.

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Pearson, M., Pelicci, P. PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene 20, 7250–7256 (2001). https://doi.org/10.1038/sj.onc.1204856

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