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Beyond the RING: CBL proteins as multivalent adapters

Oncogene volume 20, pages 6382–6402 (2001)Cite this article

Abstract

Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular adapters and protein tyrosine kinases. It appears that Cbl proteins play several functional roles, acting both as multivalent adapters and inhibitors of various protein tyrosine kinases. The latter function is linked, to a substantial extent, to the E3 ubiquitin-ligase activity of Cbl proteins. Experimental evidence for these functions, interrelations between them, and their biological significance are addressed in this review, with the main accent placed on the adapter functions of Cbl proteins.

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Abbreviations

BCR:

B-cell receptor

CSF-1:

colony-stimulating factor-1

EGF:

epidermal growth factor

ECM:

extracellular matrix

EPO:

erythropoietin

FGF:

fibroblast growth factor

GM-CSF:

granulocyte-macrophage colony-stimulating factor

GST:

glutathione-S-transferase

IFN:

interferon

IL:

interleukin

NGF:

nerve growth factor

PI-3′ kinase:

phosphatidylinositol-3′ kinase

PMA:

phorbol 12-myristate 13-acetate

PKC:

protein kinase C

PDGF:

platelet-derived growth factor

PTK:

protein tyrosine kinase

SCF:

stem cell factor

TCR/CD3:

T-cell receptor/CD3

TKB:

tyrosine kinase binding (domain)

TPO:

thrombopoietin.

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Acknowledgements

The authors thank Greg Harvey for excellent editorial help. This work is supported by the National Institutes of Health grant CA78499 (to AY Tsygankov).

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  1. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, Pennsylvania, USA

    Alexander Y Tsygankov, Anjali M Teckchandani, Elena A Feshchenko & Gayathri Swaminathan

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  2. Anjali M Teckchandani
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Tsygankov, A., Teckchandani, A., Feshchenko, E. et al. Beyond the RING: CBL proteins as multivalent adapters. Oncogene 20, 6382–6402 (2001). https://doi.org/10.1038/sj.onc.1204781

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