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The role of Gads in hematopoietic cell signalling

Oncogene volume 20, pages 6284–6290 (2001)Cite this article

Abstract

Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT. This complex couples the T cell receptor to Ras through a novel pathway involving PLC-γ1, Tec family kinases, and RasGRP. Studies with Gads-deficient mice have highlighted its importance for thymocyte proliferation during T cell maturation. Emerging evidence suggests that Gads may also play additional roles in antigen-receptor signalling and receptor tyrosine kinase mediated signalling in other hematopoietic lineages. Gads is a unique member of the Grb2 adaptor family, because its activity can be regulated by caspase cleavage. Gads nucleates multi-protein complexes that are required for tyrosine kinase-dependent signalling in immune cells and may also represent a point of modulation for these pathways through the activation of caspase-dependent signalling events.

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Acknowledgements

We would like to thank Alec Cheng, Thomas Yankee, Edward Clark, Kazuo Sugamura and Guy Mouchiroud for communicating results prior to publication. We also acknowledge the support of the Cancer Research Society, Inc., Canada, and the Canadian Institutes of Health Research. CJ McGlade is a Research Scientist of the National Cancer Institute of Canada supported by funds from the Canadian Cancer Society.

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  1. The Hospital for Sick Children and Department of Medical Biophysics, The Arthur and Sonia Labatt Brain Tumour Research Centre, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Ontario, Canada

    Stanley K-W Liu, Donna M Berry & C Jane McGlade

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  1. Stanley K-W Liu
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Correspondence to C Jane McGlade.

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Liu, SW., Berry, D. & McGlade, C. The role of Gads in hematopoietic cell signalling. Oncogene 20, 6284–6290 (2001). https://doi.org/10.1038/sj.onc.1204771

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