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Chromatin remodelling and DNA replication: from nucleosomes to loop domains

Oncogene volume 20, pages 3086–3093 (2001)Cite this article

Abstract

Organization of DNA into chromatin is likely to participate in the control of the timing and selection of DNA replication origins. Reorganization of the chromatin is carried out by chromatin remodelling machines, which may affect the choice of replication origins and efficiency of replication. Replication itself causes a profound rearrangement in the chromatin structure, from nucleosomes to DNA loop domains, allowing to retain or switch an epigenetic state. The present review considers the effects of chromatin remodelling on replication and vice versa.

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Acknowledgements

We thank Drs D Fisher and J-M Lemaître for critical reading of the manuscript. The authors' research was supported by C.N.R.S., Association pour la Recherche sur le Cancer, and Fondation pour la Recherche Médicale.

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  1. Caroline Demeret

    Present address: Institut Pasteur, 25 rue du Docteur Roux, Paris, 75015, France

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  1. Institute of Human Genetics, CNRS, 141, rue de la Cardonille, Montpellier, 34396, Cedex 5, France

    Caroline Demeret, Yegor Vassetzky & Marcel Méchali

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Demeret, C., Vassetzky, Y. & Méchali, M. Chromatin remodelling and DNA replication: from nucleosomes to loop domains. Oncogene 20, 3086–3093 (2001). https://doi.org/10.1038/sj.onc.1204333

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