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Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma

Oncogene volume 20, pages 399–403 (2001)Cite this article

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (TRAIL-R1) and tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) are cell-surface receptors involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. TRAIL-R1 and TRAIL-R2 genes have recently been mapped to chromosome 8p21-22, which is a frequent site of allelic deletions in many types of human tumors, including non-Hodgkin's lymphoma (NHL). Because TRAIL/TRAIL receptor system plays an important role in lymphocyte homeostasis, we hypothesized that the mutations of TRAIL-R1 and TRAIL-R2 may be involved in the development of NHL and that such mutations may be responsible for the allelic losses of 8p21-22 in NHL. In this study, we analysed the entire coding region of TRAIL-R2 gene and the death domain region of TRAIL-R1 gene for the detection of the somatic mutations in a series of 117 human NHLs using polymerase chain reaction (PCR)-based single strand conformation polymorphism (SSCP) analysis. Overall, eight tumors (6.8%) were found to have two TRAIL-R1 gene mutations or six TRAIL-R2 gene mutations. Interestingly, of the eight mutations, six missense mutations (two TRAIL-R1 and four TRAIL-R2) were detected in the death domains and one nonsense mutation of TRAIL-R2 was detected just before the death domain. Our data suggest that somatic mutations of TRAIL-R1 and TRAIL-R2 genes may play a role in the pathogenesis of some NHLs and that TRAIL-R1 and TRAIL-R2 genes might be the relevant genes to the frequent loss of chromosome 8p21-22 in human NHL.

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Acknowledgements

This work was supported by grant (No. 1999-2-20700-002-5) from the Basic Research Program of the Korea Science & Engineering Foundation.

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  1. Sug Hyung Lee and Min Sun Shin: Sug Hyung Lee and Min Sun Shin contributed equally to this work

Authors and Affiliations

  1. Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea

    Sug Hyung Lee, Min Sun Shin, Hong Sug Kim, Hun Kyung Lee, Won Sang Park, Su Young Kim, Jong Heun Lee, Seo Young Han, Jik Young Park, Ro Ra Oh, Jung Young Lee & Nam Jin Yoo

  2. Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, 137-701, Korea

    Chang Suk Kang & Kyung Mee Kim

  3. Department of Pathology and Cancer Research Center, Seoul National University College of Medicine, Seoul, 110-799, Korea

    Ja June Jang

  4. Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD, USA

    Suk Woo Nam

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Lee, S., Shin, M., Kim, H. et al. Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma. Oncogene 20, 399–403 (2001). https://doi.org/10.1038/sj.onc.1204103

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