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RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

Oncogene volume 19, pages 592–598 (2000)Cite this article

This article was retracted on 24 April 2023

This article has been updated

Abstract

In addition to their role in anogenital cancer, human papillomaviruses (HPVs) are also involved in the development of a range of cutaneous lesions. HPV types 5 and 8 are associated with the development of skin cancers in individuals with Epidermodysplasia verruciformis (EV). A broad spectrum of HPV types are also commonly found in non-melanoma skin cancers in immunocompromised individuals, such as organ transplant recipients. The skin cancers in EV and immunocompromised patients occur predominantly at body sites exposed to ultra violet (UV) radiation, pointing to a key role for UV in their development. Here we show that the E6 protein from a range of cutaneous HPV types effectively inhibits apoptosis in response to UV damage. This occurs in both p53 null and wild type cells and does not require p53 degradation.

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Acknowledgements

S Jackson was the recipient of a BBSRC Industrial CASE studentship in association with Roche Products. We thank Prof AG Quinn for comments on the manuscript. We are especially grateful to Derek Davies and Aaron Rae of the ICRF FACS laboratory for performing cell cycle analysis.

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  1. ICRF Skin Tumour Laboratory, Centre for Cutaneous Research, 2, Newark Street, London, E1 2AT, UK

    Sarah Jackson & Alan Storey

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Jackson, S., Storey, A. RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage. Oncogene 19, 592–598 (2000). https://doi.org/10.1038/sj.onc.1203339

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