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Myc-mediated transformation: the repression connection

Oncogene volume 18, pages 2925–2933 (1999)Cite this article

Abstract

Myc is an important regulator of many cellular processes, including growth promotion, differentiation, and apoptosis. The mechanisms underlying Myc biological activity, however, remain elusive. For many years, research in the field has focused on the idea of Myc as a transactivator of gene expression. More recently, alternative mechanisms of Myc function have been proposed, including gene repression. In this review we present several lines of evidence to support a connection between Myc-mediated transformation and transcriptional repression.

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Acknowledgements

We would like to thank Linda Penn, Sara Oster, Rebecca Chinery, Qiurong Xiao, Juliet Daniel, and Mark Gregory for critical reading. We would also like to thank Linda Penn and Gail Sonenshein for sharing their data for the purpose of this review.

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  1. Department of Cell Biology, Vanderbilt University, Nashville, TN 37232, Tennessee, USA

    Gisela F Claassen & Stephen R Hann

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  1. Gisela F Claassen
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Claassen, G., Hann, S. Myc-mediated transformation: the repression connection. Oncogene 18, 2925–2933 (1999). https://doi.org/10.1038/sj.onc.1202747

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