Abstract
Wild type p53 expressed from a temperature-sensitive (ts p53) construct induces both G1 cell cycle arrest and apoptosis in the p53-negative J3D mouse T lymphoma line (Wang et al., 1995). Using differential display analysis, we have identified one new p53-induced gene, wig-1 (for wild type p53-induced gene 1), whose 7.6 kb and 2.2 kb transcripts are upregulated in ts p53-transfected J3D cells following induction of wild type p53 expression by temperature shift to 32°C. The wig-1 transcripts were also induced in irradiated NIH3T3 and p21−/− fibroblasts but not in irradiated p53−/− fibroblasts. Whole body gamma irradiation caused induction of both wig-1 transcripts in mouse brain, testis, kidney, spleen and lung. A basal wig-1 expression was detected in brain, testis and kidney. The WIG-1 protein contains three zinc finger motifs and a putative nuclear localization signal.
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Varmeh-Ziaie, S., Okan, I., Wang, Y. et al. Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene 15, 2699–2704 (1997). https://doi.org/10.1038/sj.onc.1201454
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DOI: https://doi.org/10.1038/sj.onc.1201454
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