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The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p

Oncogene volume 14, pages 1753–1757 (1997)Cite this article

Abstract

Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.

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Authors and Affiliations

  1. Centre de Recherche de Biochimie Macromolécularie, CNRS ERS 155-INSERM U249, route de Mende, BP5051, Montpellier Cedex, 34033, France

    P Jay, C Marsollier, C Méjean, S Taviaux & P Berta

  2. INSERM U406, Faculté de Médecine, boulevard Jean Moulin, Marseille Cedex, 13385, France

    J L Bergé-Lefranc

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  1. P Jay
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  2. J L Bergé-Lefranc
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  3. C Marsollier
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  4. C Méjean
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  5. S Taviaux
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  6. P Berta
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Jay, P., Bergé-Lefranc, J., Marsollier, C. et al. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. Oncogene 14, 1753–1757 (1997). https://doi.org/10.1038/sj.onc.1200986

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  • DOI: https://doi.org/10.1038/sj.onc.1200986

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