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Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease

International Journal of Obesity volume 30, pages 209–213 (2006)Cite this article

Abstract

Background:

No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease.

Patients and methods:

We genotyped a tetranucleotide repeat mapped in the 3′UTR of the LEP gene (LEP-tet) in 109 subjects with cardiovascular events and in 109 control subjects.

Results:

Univariate analysis and multivariate logistic regression analysis adjusted for age, gender, smoking status, history of hyperlipidemia, hypertension or diabetes showed not significant association between the genotype of the LEP-tet and cardiovascular diseases. Moreover, no differences were observed in the plasma leptin concentrations between cases and control subjects (22±19 vs 22±14 ng/ml, P=0.52) and in relation to the LEP-tet classes or carriage of specific allelels (P=0.76 for the association between LEP-tet classes and leptin levels in overall analysis).

Conclusions:

In conclusion, our data do not support an association between the LEP-tet microsatellite polymorphism of the human LEP gene and cardiovascular diseases.

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Authors and Affiliations

  1. Department of Medicine and Aging and Department of Biomedical Sciences, and Aging Research Center, CeSI., GD'Annunzio University Foundation, Chieti-Pescara, Italy

    E Porreca, C Di Febbo, S Pintor, G Baccante, V Gatta, V Moretta, M Di Nisio, F Cuccurullo & L Stuppia

  2. CSS-Mendel, Rome, Italy

    C Palka

  3. ITOI-CNR Bologna, Bologna, Italy

    L Stuppia

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  1. E Porreca
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  2. C Di Febbo
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  3. S Pintor
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  4. G Baccante
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  5. V Gatta
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  6. V Moretta
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  7. M Di Nisio
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Correspondence to E Porreca.

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Porreca, E., Di Febbo, C., Pintor, S. et al. Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. Int J Obes 30, 209–213 (2006). https://doi.org/10.1038/sj.ijo.0803150

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  • DOI: https://doi.org/10.1038/sj.ijo.0803150

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