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Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity

International Journal of Obesity volume 29, pages 872–874 (2005)Cite this article

Abstract

OBJECTIVE:

To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity.

METHODS:

The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m2), and nonobese (BMI ranging from 16.0 to 29.4 kg/m2). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis.

RESULTS:

BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnical backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect.

CONCLUSION:

We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity.

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Acknowledgements

We acknowledge Ming D Yang and Hiwote T Belay for techniqual support. This work was supported in part by NIH Grants P30DK056336 and T32HL072757 and a research grant from the Canada Research Chairs Program to MBS.

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Authors and Affiliations

  1. Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA

    S O Zakharkin, J R Fernandez & D B Allison

  2. Department of Biology, University of Toronto at Mississauga, Mississauga, Ontario, Canada

    A T Belay & M B Sokolowski

  3. Clinical Nutrition Research Center, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA

    J R Fernandez & D B Allison

  4. Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

    V De Luca & J L Kennedy

Authors
  1. S O Zakharkin
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  2. A T Belay
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  3. J R Fernandez
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  4. V De Luca
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  5. J L Kennedy
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  6. M B Sokolowski
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  7. D B Allison
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Correspondence to D B Allison.

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Zakharkin, S., Belay, A., Fernandez, J. et al. Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity. Int J Obes 29, 872–874 (2005). https://doi.org/10.1038/sj.ijo.0802973

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  • DOI: https://doi.org/10.1038/sj.ijo.0802973

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