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Obesity-related correlation between C-reactive protein and the calculated 10-y Framingham Coronary Heart Disease Risk Score

International Journal of Obesity volume 29, pages 772–777 (2005)Cite this article

Abstract

OBJECTIVE:

To clarify the role of body mass index (BMI, kg/m2) adjustment in predictive models for cardiovascular events that add high-sensitivity C-reactive protein (hs-CRP) to the 10-y Framingham Coronary Heart Disease Risk Score (FCRS).

DESIGN:

A cross-sectional study in a group of apparently healthy individuals.

SUBJECTS:

In all, 1512 apparently healthy individuals (955 men and 557 women) at a respective age of 49.7±10.6 and 50.6±9.6 y.

RESULTS:

The Pearson correlation between hs-CRP and the calculated 10-y FCRS was lower when adjusted for BMI. This reduction was especially noted in women where it dropped from 0.247 to 0.09. The dominant role of hs-CRP concentrations was also noted in a linear regression model, again, especially noted in women (drop of the standardized coefficient from 0.517 for BMI to 0.08 for the FCRS).

CONCLUSIONS:

The correlation between hs-CRP and the 10-y FCRS is partly related to the presence of obesity. We raise the possibility that the addition of BMI to the predictive model of FCRS might attenuate the cost-effectiveness of CRP measurements for this specific risk assessment.

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Author notes

  1. O Rogowski and I Shapira: Both these authors contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine ‘D’ and Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    O Rogowski, I Shapira, S Toker, S Berliner & D Zeltser

  2. Faculty of Management, Tel-Aviv University, Tel-Aviv, Israel

    S Toker & A Shirom

  3. National Institute of Occupational & Environmental Health, Raanana, affiliated to Sackler Faculty Medicine, Tel-Aviv University, Tel-Aviv, Israel

    S Melamed

Authors
  1. O Rogowski
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  2. I Shapira
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  3. S Toker
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  4. S Melamed
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  5. A Shirom
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  6. S Berliner
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  7. D Zeltser
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Corresponding author

Correspondence to S Berliner.

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Rogowski, O., Shapira, I., Toker, S. et al. Obesity-related correlation between C-reactive protein and the calculated 10-y Framingham Coronary Heart Disease Risk Score. Int J Obes 29, 772–777 (2005). https://doi.org/10.1038/sj.ijo.0802939

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