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How does sibutramine work?

International Journal of Obesity volume 25, pages S8–S11 (2001)Cite this article

Abstract

Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects—a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.

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  1. Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK

    MEJ Lean

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  1. MEJ Lean
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Correspondence to MEJ Lean.

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Lean, M. How does sibutramine work?. Int J Obes 25 (Suppl 4), S8–S11 (2001). https://doi.org/10.1038/sj.ijo.0801931

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  • DOI: https://doi.org/10.1038/sj.ijo.0801931

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