Abstract
OBJECTIVE: To investigate whether menopausal state, body composition and lifestyle factors influence total and regional bone mineral density in overweight Japanese women.
DESIGN: Cross-sectional study of women who were recruited to the weight reduction program held at community-based health promotion center in Tokyo area.
Subjects: A total of 178 women with a mean age of 48 y old (20–69 y) with a clear menstrual history and BMI over 24.
MEASUREMENTS: Total, regional and lumbar spine bone mineral density (BMD) and body composition were measured using DXA (Lunar). Menstrual history was taken by a questionnaire and walking steps per day and energy intake were measured. Physical fitness was assessed by cardio-respiratory fitness and leg extension power. Subjects were divided into pre-menopausal and post-menopausal groups.
RESULTS: Pre-menopausal group had significantly higher total body BMD as well as regional BMD than post-menopausal group. However, no differences in BMI, percentage fat and fat mass (FM) were seen between the two groups. The multiple regression analysis stepwise method revealed that total and regional BMD correlated with menopausal state and total FM independently. Total and regional BMD did not correlated with total non-fat soft tissue mass (NFSM), energy intake, walking steps or physical fitness levels. Trunk and lower extremities BMD correlated with corresponding regional FM and NFSM, and upper extremities BMD correlated with only corresponding body part NFSM after adjusting menopausal state.
CONCLUSION: Total and regional BMD had strong negative correlation with menopausal state rather than total FM in overweight Japanese women. Weight-bearing site BMD correlated with corresponding body part FM and NFSM and non-weight bearing site BMD only correlated with corresponding body part NFSM after adjusting for menopausal state.
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References
Kurokawa K, Inoue T, Orimo H . Osteoporosis. Recent advances in pathophysiology, diagnosis and management Jap Med Assoc Tokyo 1996 28–31 (in Japanese).
Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM . Bone density at various site for prediction of hip fractures Lancet 1993 341: 72–75.
Melton LJ III . Epidemiology of spinal osteoporosis Spine 1997 22 (24 Suppl): 2S–11S.
Suzuki T, Nagai H, Shibata C, Amano H, Kumagai S, Watanabe S, Yasumura S, Haga H . Factors relating to the bone mineral density in the elderly living in the urban community J Epidemiol 1994 4: 83–89.
Aloia JF, McGowan DM, Vaswani AN, Ross P, Cohn SH . Relationship of menopause to skeletal and muscle mass Am J Clin Nutr 1991 53: 1378–1383.
Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES . Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density J Clin Endocrinol Metab 1995 80: 1118–1123.
Reid IR, Ames RW, Evans MC, Sharpe SJ, Gamble GD . Determinants of the rate of bone loss in normal postmenopausal women J Clin Endocrinol Metab 1994 79: 950–954.
Pritchard JE, Nowson CA, Wark JD . Bone loss accompanying diet-induced or exercise-induced weight loss: a randomized controlled study Int J Obes Relat Metab Disord 1996 20: 513–520.
Baumgartner RN, Stauber PM, Koehler KM, Romero L, Garry PJ . Associations of fat and muscle masses with bone mineral in elderly men and women Am J Clin Nutr 1996 63: 365–372.
Aloia JF, Vaswani A, Ma R, Flaster E . To what extent is bone mass determined by fat-free or fat mass? Am J Clin Nutr 1995 61: 1110–1114.
Salamone LM, Glynn NW, Black DM, Epstein RS, Palermo L, Meilahn E, Kuller LH, Cauley JA . Body composition and bone mineral density in premenopausal and early perimenopausal women J Bone Mineral Res 1995 10: 1762–1768.
Khosla S, Atkinson EJ, Riggs BL, Melton LJ 3rd . Relationship between body composition and bone mass in women J Bone Mineral Res 1996 11: 857–863.
Ministry of Heath and Welfare . National Health and Nutrition Survey Daiichi: Tokyo 1999.
Daniels ED, Pettifor JM, Schnitzler CM, Russell SW, Patel DN . Ethnic differences in bone density in female South African nurses J Bone Mineral Res 1995 10: 359–367.
Pouilles JM, Tremollieres F, Ribot C . Spine and femur densitometry at the menopause: are both sites necessary in the assessment of the risk of osteoporosis? Calcif Tissue Int 1993 52: 334–347.
Wang Q, Hassager C, Ravn P, Wang S, Christiansen C . Total and regional body-composition changes in early postmenopausal women: age-related or menopause-related? Am J Clin Nutr 1994 60: 843–848.
Hendel HW, Gotfredsen A, Andersen T, Hojgaard L, Hilsted J . Body composition during weight loss in obese patients estimated by dual energy X-ray absorptiometry and by total body potassium Int J Obes Relat Metab Disord 1996 20: 1111–1119.
Miyashita M, Mutoh Y, Yoshioka N, Sadamoto T . PWC75%HRmax: a measure of aerobic work capacity Sports Med 1985 2: 159–164.
Ito M, Yada Y . Development of an apparatus to measure instantaneous leg extension power out put Jap J Sports Sci 1992 11: 742–746 (in Japanese with English abstract).
Lees B, Stevenson JC . An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry Osteoporosis Int 1992 2: 146–152.
Kajita E, IKI M, Nishimura H, Dohi Y, Moriyama T, Tobita Y, Deguchi Y, Kusaka Y, Ogata A . Bone mineral density of the lumbar spine and its relation to biological and lifestyle factors in middle-aged and aged Japanese women. (Part 1) Relationship of age and menopause to bone mineral density of the lumbar spine measured by dual-energy X-ray absorptiometry Jap J Hygiene 1994 49: 674–683 (in Japanese with English abstract).
Kasamatsu T, Yoshimura N, Morioka S, Sugita K, Hashimoto T . A population survey on bone mineral density in a fishing village in Wakayama prefecture. (Part 1) Distribution of bone mineral density by sex and age on a representative sample of the community Jap J Hygiene 1996 50: 1084–1092. (in Japanese with English abstract).
Rubin CD . Age-related osteoporosis Am J Med Sci 1991 301: 281–298.
Nilas L, Christiansen C . Bone mass and its relationship to age and the menopause J Clin Endocrinol Metab 1987 65: 697–702.
Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III . Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis J Clin Invest 1981 67: 328–335.
Kim H, Tanaka K, Nakanishi T, Amagai H . Effects of age and body composition on rate of bone mineral density loss in Japanese adult women Jap J Phys Fitness Sports Med 1999 48: 81–90 (in Japanese with English abstract).
Kin K, Kushida K, Yamazaki K, Okamoto S, Inoue T . Bone mineral density of the spine in normal Japanese subjects using dual-energy X-ray absorptiometry: effect of obesity and menopausal status Calcif Tissue Int 1991 49: 101–106.
Alabala C, Yanez M, Devoto E, Sostin C, Zeballos L, Santos JL . Obesity as a protective factor for postmenopausal osteoporosis Int J Obes Relat Metab Disord 1996 20: 1027–1032.
Ohmura A, Kushida K, Yamazaki K, Okamoto S, Katsuno H, Inoue T . Bone mineral density and body composition in Japanese women Calif Tissue Int 1997 61: 117–122.
Mazess RB, Peppler WW, Chesney RW, Lange TA, Lindgren U, Smith E . Total body and regional bone mineral by dual-photon absorptiometry in metabolic bone disease Calif Tissue Int 1984 36: 8–13.
Hla MM, Davis JW, Ross PD, Wasnich RD, Yates AJ, Ravn P, Hosking DJ, McClung MR . A multicenter study of the influence of fat and lean mass on bone mineral content: evidence for differences in their relative influence at major fracture sites. Early Postmenopausal Intervention Cohort (EPIC) Study Group Am J Clin Nutr 1996 64: 354–360.
Acknowledgements
We are grateful to the participants of the weight-reduction program who willingly performed the DXA measurement. We also thank the technologists who performed DXA measurement at the Tanita Company.
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Lee, J., Kawakubo, K., Sato, H. et al. Relationship between total and regional bone mineral density and menopausal state, body composition and life style factors in overweight Japanese women. Int J Obes 25, 880–886 (2001). https://doi.org/10.1038/sj.ijo.0801620
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DOI: https://doi.org/10.1038/sj.ijo.0801620