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Risk factors for coronary heart disease in obese non-diabetic subjects

International Journal of Obesity volume 25, pages 1042–1046 (2001)Cite this article

Abstract

OBJECTIVE: To examine relationships between body mass index (BMI) and coronary risk factors in obese subjects presenting to a dedicated obesity clinic.

STUDY DESIGN: Cross-sectional population survey from a single centre.

SUBJECTS: Three hundred and eighty-six consecutive non-diabetic obese subjects (301 women, 85 men) attending an obesity clinic for the first time (mean BMI 43.3 kg/m2; range 30.6–71.5), aged 17–69 y (mean 40.1).

MEASUREMENTS: Height, weight, resting blood pressure, fasting plasma cholesterol, triglyceride, glucose and uric acid concentrations.

RESULTS: All variables measured showed an increase with higher BMI (triglycerides, P=0.04; glucose, P=0.007; urate, P<0.001; systolic BP, P<0.001; diastolic BP, P<0.001) as measured by one-way ANOVA, except cholesterol concentration which showed no relationship with BMI. In comparison with the group of subjects with BMI 30–35 kg/m2 mean values for all variables were higher in the more obese subjects.

CONCLUSIONS: Non-diabetic subjects with BMI>35 kg/m2 carry a burden of common coronary risk factors which appears to increase with greater obesity. The risk factor pattern observed echoes that described in insulin resistance syndromes. Plasma cholesterol concentration appears not to be related to BMI.

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References

  1. Pi-Sunyer FX . Medical hazards of obesity Ann Intern Med 1993 119: 655–660.

    Article  CAS  Google Scholar 

  2. Hubert HB, Feinleib M, McNamara PM, Castelli WP . Obesity as an independent risk factor for cardiovascular disease: a 26-y follow-up of participants in the Framingham Heart Study Circulation 1983 67: 968–977.

    Article  CAS  Google Scholar 

  3. Bender R, Trautner C, Spraul M, Berger M . Assessment of excess mortality in obesity Am J Epidemiol 1998 147: 42–48.

    Article  CAS  Google Scholar 

  4. Manson JE, Colditz GA, Stampfer MJ, Willett WC, Rosner B, Monson RR, Speizer FE, Hennekens CH . A prospective study of obesity and risk of coronary heart disease in women New Engl J Med 1990 322: 882–889.

    Article  CAS  Google Scholar 

  5. White FMM, Pereira LH, Garner JB . Association of body mass index and waist-hip ratio with hypertension Can Med Assoc J 1986 135: 313–320.

    CAS  Google Scholar 

  6. Spiegelman D, Israel RG, Bouchard C, Willett WC . Absolute fat mass, percent body fat, and body fat distribution: which is the real determinant of blood pressure and serum glucose? Am J Clin Nutr 1992 55: 1033–1944.

    Article  CAS  Google Scholar 

  7. Guagnano MT, Ballone E, Merlitti D, Murri R, Pace-Palitti V, Pilotti R, Sensi S . Association between anthropometric and ultrasound measurements of fatness with ambulatory blood pressure monitoring in obese women Int J Obes Relat Metab Disord 1997 21: 632–636.

    Article  CAS  Google Scholar 

  8. Folsom AR, Stevens JH, Schreiner PJ, McGovern PG . Body mass index, waist/hip ratio, and coronary heart disease incidence in African Americans and whites Am J Epidemiol 1998 148: 1187–1194.

    Article  CAS  Google Scholar 

  9. Peiris AN, Sothmann MS, Hoffmann GE, Hennes MI, Wilson CR, Gustafson AB, Kissebah AH . Adiposity, fat distribution and cardiovascular risk Ann Intern Med 1989 110: 867–872.

    Article  CAS  Google Scholar 

  10. Young TK, Gelskey DE . Is noncentral obesity metabolically benign? Implications for prevention from a population survey JAMA 1995 274: 1939–1941.

    Article  CAS  Google Scholar 

  11. Landin K, Krotkiewski M, Smith U . Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution Metabolism 1989 38: 572–576.

    Article  CAS  Google Scholar 

  12. Reaven GM . Role of insulin resistance in human disease Diabetes 1998 37: 1595–1607.

    Article  Google Scholar 

  13. Facchini F, Chen Y-Di, Hollenbeck CB, Reaven GM . Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration JAMA 1991 266: 3008–3011.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The Obesity Clinic, Leeds General Infirmary, Leeds, UK

    DC Whitelaw, M O'Kane, JK Wales & JH Barth

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  1. DC Whitelaw
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  2. M O'Kane
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  3. JK Wales
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  4. JH Barth
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Correspondence to DC Whitelaw.

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Whitelaw, D., O'Kane, M., Wales, J. et al. Risk factors for coronary heart disease in obese non-diabetic subjects. Int J Obes 25, 1042–1046 (2001). https://doi.org/10.1038/sj.ijo.0801596

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  • DOI: https://doi.org/10.1038/sj.ijo.0801596

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