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Enhanced intra-abdominal visceral fat accumulation in patients with Werner's syndrome

International Journal of Obesity volume 25, pages 292–295 (2001)Cite this article

Abstract

OBJECTIVE: Studies were made on the abnormality of glucose and lipid metabolism and its cause in four patients with Werner's syndrome to infer the reason for accelerated atherogenesis in this syndrome.

RESULTS: Of these four patients, hypercholesterolemia was found in three, hypertriglyceridemia in four, hypoalphalipoproteinemia in two and hypertension in two. All the patients had insulin-resistant diabetes mellitus and three of them had apparent hyperinsulinemia. Abdominal computed tomography revealed that all of them had visceral fat obesity, namely augumented intra-abdominal adipose tissue.

CONCLUSION: The clinical features of these patients resemble those recently designated as insulin resistant syndrome (syndrome X) or visceral fat syndrome. The metabolic abnormality may be one of important factors in the accelerated atherogenesis in this syndrome.

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Acknowledgements

This work was supported by grants from the Ministry of Education, Science, Sports and Culture of Japan (nos 11144206 and 11838002) and from the Sumitomo Foundation for Medicine and Welfare.

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  1. Second Department of Internal Medicine, School of Medicine, Chiba University, Inohana, Chiba, Japan

    S Mori, K Yokote, M Takemoto, S Asaumi, A Take & Y Saito

  2. Department of Internal Medicine, Shimotsuga General Hospital, Fujimi, Tochigi, Japan

    S Murano

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  1. S Mori
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Correspondence to S Mori.

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Mori, S., Murano, S., Yokote, K. et al. Enhanced intra-abdominal visceral fat accumulation in patients with Werner's syndrome. Int J Obes 25, 292–295 (2001). https://doi.org/10.1038/sj.ijo.0801529

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