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The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

International Journal of Obesity volume 23, pages S49–S50 (1999)Cite this article

Abstract

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

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Authors and Affiliations

  1. Departments of Pediatrics and Medicine, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, Naomi Berrie Diabetes Center, Russ Berrie Medical Science Pavilion, 1150 St. Nicholas Avenue, New York, 10032, NY, USA

    WK Chung, M Rosenbaum, R Goldsmith & RL Leibel

  2. Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 TS. First Avenue, Maywood, 60153, IL, USA

    A Luke, RS Cooper & C Rotini

  3. Division of Endocrinology, Beth Israel-Deaconess Medical Center, 330 Brookline Avenue, Boston, 02215, MA, USA

    A Vidal-Puig & BB Lowell

  4. The Rockefeller University, 1230 York Avenue, New York, 10021, NY, USA

    D Gordon & SM Leal

  5. Division of Pediatric Endocrinology, Yale University School of Medicine, 333 Cedar Street, New Haven, 06510, CT, USA

    S Caprio

  6. St Luke’s / Roosevelt Hospital Center, Obesity Research Center, Columbia University College of Physicians and Surgeons, 1090 Amsterdam Avenue, New York, 10025, NY, USA

    AL Andreu, C Bruno & S DiMauro

  7. Department of Medicine, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, 60611, IL, USA

    C Bruno

  8. Columbia University College of Physicians & Surgeons, H. Houston Merritt Clinical Research Centre for Muscular Dystrophy and Related Diseases, 630 West 168th Street, New York, 10032, NY, USA

    M Heo, WL Lowe (Jr) & DB Allison

Authors
  1. WK Chung
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  2. A Luke
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  3. RS Cooper
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  4. C Rotini
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  5. A Vidal-Puig
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  6. M Rosenbaum
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  7. D Gordon
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  8. SM Leal
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  9. S Caprio
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  10. R Goldsmith
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  11. AL Andreu
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  12. C Bruno
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  13. S DiMauro
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  14. M Heo
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  15. WL Lowe (Jr)
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  16. BB Lowell
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  17. DB Allison
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  18. RL Leibel
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Corresponding author

Correspondence to RL Leibel.

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Cite this article

Chung, W., Luke, A., Cooper, R. et al. The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. Int J Obes 23 (Suppl 6), S49–S50 (1999). https://doi.org/10.1038/sj.ijo.0800945

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