Volume 44 Issue 9, September 2023
Cover Credit: Bergapten on NLRP3 inflammasome in inflammatory diseases
Inhibition of NLRP3 inflammasome activation produces potent therapeutic effects in a wide array of inflammatory diseases. The schematic describes that bergapten, a natural organic compound in herbal medicines and fruits, effectively inhibits NLRP3 inflammasome activation, cytokine release, and pyroptosis through maintenance of mitochondrial homeostasis by promoting mitophagy, suggesting its potential role in suppressing the inflammatory response. See the article in pages 1867–1878.
