Latest Research

  • Article |

    The balance of DELLA and GRF4 proteins in plants ensures the co-regulation of growth with metabolism and tipping this balance towards GRF4 leads to higher efficiency of nitrogen use.

    • Shan Li
    • , Yonghang Tian
    • , Kun Wu
    • , Yafeng Ye
    • , Jianping Yu
    • , Jianqing Zhang
    • , Qian Liu
    • , Mengyun Hu
    • , Hui Li
    • , Yiping Tong
    • , Nicholas P. Harberd
    •  & Xiangdong Fu
  • Letter |

    Satellite observations and Earth system model simulations reveal that marine heatwaves have increased in recent decades and will increase further in terms of frequency, intensity, duration and spatial extent.

    • Thomas L. Frölicher
    • , Erich M. Fischer
    •  & Nicolas Gruber
  • Article |

    A cryo-electron microscopy structure of the insect Orco subunit, which forms ion channels with diverse olfactory receptors, reveals a tetrameric cation channel and sheds light on insect olfaction.

    • Joel A. Butterwick
    • , Josefina del Mármol
    • , Kelly H. Kim
    • , Martha A. Kahlson
    • , Jackson A. Rogow
    • , Thomas Walz
    •  & Vanessa Ruta
  • Article |

    CPEB4 binds the mRNA of genes known to be associated with autism and shows an isoform imbalance in individuals with autism, and an equivalent imbalance in mice induces an autism-like phenotype.

    • Alberto Parras
    • , Héctor Anta
    • , María Santos-Galindo
    • , Vivek Swarup
    • , Ainara Elorza
    • , José L. Nieto-González
    • , Sara Picó
    • , Ivó H. Hernández
    • , Juan I. Díaz-Hernández
    • , Eulàlia Belloc
    • , Annie Rodolosse
    • , Neelroop N. Parikshak
    • , Olga Peñagarikano
    • , Rafael Fernández-Chacón
    • , Manuel Irimia
    • , Pilar Navarro
    • , Daniel H. Geschwind
    • , Raúl Méndez
    •  & José J. Lucas
  • Letter |

    Chronic exposure to sulfoxaflor (a sulfoximine-based insecticide) has severe sub-lethal effects on bumblebee (Bombus terrestris) colonies; exposed colonies produced fewer workers and fewer reproductive offspring than unexposed control colonies.

    • Harry Siviter
    • , Mark J. F. Brown
    •  & Ellouise Leadbeater
  • Letter |

    The bacterial metabolite ADP-heptose activates NF-κB in host cells via alpha-kinase 1 and the TIFA–TRAF signalling pathway

    • Ping Zhou
    • , Yang She
    • , Na Dong
    • , Peng Li
    • , Huabin He
    • , Alessio Borio
    • , Qingcui Wu
    • , Shan Lu
    • , Xiaojun Ding
    • , Yong Cao
    • , Yue Xu
    • , Wenqing Gao
    • , Mengqiu Dong
    • , Jingjin Ding
    • , Da-Cheng Wang
    • , Alla Zamyatina
    •  & Feng Shao
  • Letter |

    Cross-correlation analysis of high-resolution spectra obtained as the exoplanet KELT-9b transited its host star reveals neutral and singly ionized atomic iron and singly ionized atomic titanium in the exoplanet’s atmosphere.

    • H. Jens Hoeijmakers
    • , David Ehrenreich
    • , Kevin Heng
    • , Daniel Kitzmann
    • , Simon L. Grimm
    • , Romain Allart
    • , Russell Deitrick
    • , Aurélien Wyttenbach
    • , Maria Oreshenko
    • , Lorenzo Pino
    • , Paul B. Rimmer
    • , Emilio Molinari
    •  & Luca Di Fabrizio

Latest Reviews & Analysis

  • News & Views |

    A previously unknown pathway that enables mammalian cells to recognize infection and trigger an immune response requires a kinase enzyme in the host cell to bind a sugar molecule produced by infecting bacteria.

    • John-Demian Sauer
  • News & Views |

    Manipulation of the transcription factor OsGRF4 can improve the efficiency with which some high-yielding cereal crops use nitrogen. This discovery has implications for sustainable agriculture.

    • Fanmiao Wang
    •  & Makoto Matsuoka
  • News & Views |

    Catalysts working in pairs can promote more-effective reactions than can the same catalysts used sequentially. The coupling of an enzyme with a light-activated catalyst offers great potential for organic synthesis.

    • Nicholas J. Turner
  • News & Views |

    Exposure to a sulfoximine-based pesticide has substantial adverse effects on bumblebee colonies. This finding suggests that concerns over the risks of exposing bees to insecticides should not be limited to neonicotinoids.

    • Nigel E. Raine
  • News & Views |

    Neutrinos are tiny, ghost-like particles that habitually change identity. A measurement of the rate of change in high-energy neutrinos racing through Earth provides a record-breaking test of Einstein’s special theory of relativity.

    • Matthew Mewes

News & Comment

Nature Outlook

Alzheimer’s disease

Giulio Bonasera

Alzheimer’s disease

Alzheimer’s disease is the most common form of dementia. For decades, researchers have sought a treatment to no avail, and our understanding of the condition is now being questioned.