Latest Research

  • Article |

    Studies of humans, mice and nematodes reveal a conserved role of neural activity and the transcription factor REST in extended longevity.

    • Joseph M. Zullo
    • , Derek Drake
    • , Liviu Aron
    • , Patrick O’Hern
    • , Sameer C. Dhamne
    • , Noah Davidsohn
    • , Chai-An Mao
    • , William H. Klein
    • , Alexander Rotenberg
    • , David A. Bennett
    • , George M. Church
    • , Monica P. Colaiácovo
    •  & Bruce A. Yankner
  • Letter |

    Species comparisons using single-cell transcriptomics and accessible chromatin profiling in stem cell-derived cerebral organoids are used to map dynamic gene-regulatory changes that are unique to humans.

    • Sabina Kanton
    • , Michael James Boyle
    • , Zhisong He
    • , Malgorzata Santel
    • , Anne Weigert
    • , Fátima Sanchís-Calleja
    • , Patricia Guijarro
    • , Leila Sidow
    • , Jonas Simon Fleck
    • , Dingding Han
    • , Zhengzong Qian
    • , Michael Heide
    • , Wieland B. Huttner
    • , Philipp Khaitovich
    • , Svante Pääbo
    • , Barbara Treutlein
    •  & J. Gray Camp
  • Article |

    The transcription factor TCF7L2 mediates two important responses to nicotine in the medial habenula region of the rodent brain: aversion to nicotine, and regulation of blood sugar levels through a polysynaptic habenula–pancreas circuit.

    • Alexander Duncan
    • , Mary P. Heyer
    • , Masago Ishikawa
    • , Stephanie P. B. Caligiuri
    • , Xin-an Liu
    • , Zuxin Chen
    • , Maria Vittoria Micioni Di Bonaventura
    • , Karim S. Elayouby
    • , Jessica L. Ables
    • , William M. Howe
    • , Purva Bali
    • , Clementine Fillinger
    • , Maya Williams
    • , Richard  M. O’Connor
    • , Zichen Wang
    • , Qun Lu
    • , Theodore M. Kamenecka
    • , Avi Ma’ayan
    • , Heidi C. O’Neill
    • , Ines Ibanez-Tallon
    • , Aron M. Geurts
    •  & Paul J. Kenny
  • Article
    | Open Access

    A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

    • Roy Burstein
    • , Nathaniel J. Henry
    • , Michael L. Collison
    • , Laurie B. Marczak
    • , Amber Sligar
    • , Stefanie Watson
    • , Neal Marquez
    • , Mahdieh Abbasalizad-Farhangi
    • , Masoumeh Abbasi
    • , Foad Abd-Allah
    • , Amir Abdoli
    • , Mohammad Abdollahi
    • , Ibrahim Abdollahpour
    • , Rizwan Suliankatchi Abdulkader
    • , Michael R. M. Abrigo
    • , Dilaram Acharya
    • , Oladimeji M. Adebayo
    • , Victor Adekanmbi
    • , Davoud Adham
    • , Mahdi Afshari
    • , Mohammad Aghaali
    • , Keivan Ahmadi
    • , Mehdi Ahmadi
    • , Ehsan Ahmadpour
    • , Rushdia Ahmed
    • , Chalachew Genet Akal
    • , Joshua O. Akinyemi
    • , Fares Alahdab
    • , Noore Alam
    • , Genet Melak Alamene
    • , Kefyalew Addis Alene
    • , Mehran Alijanzadeh
    • , Cyrus Alinia
    • , Vahid Alipour
    • , Syed Mohamed Aljunid
    • , Mohammed J. Almalki
    • , Hesham M. Al-Mekhlafi
    • , Khalid Altirkawi
    • , Nelson Alvis-Guzman
    • , Adeladza Kofi Amegah
    • , Saeed Amini
    • , Arianna Maever Loreche Amit
    • , Zohreh Anbari
    • , Sofia Androudi
    • , Mina Anjomshoa
    • , Fereshteh Ansari
    • , Carl Abelardo T. Antonio
    • , Jalal Arabloo
    • , Zohreh Arefi
    • , Olatunde Aremu
    • , Bahram Armoon
    • , Amit Arora
    • , Al Artaman
    • , Anvar Asadi
    • , Mehran Asadi-Aliabadi
    • , Amir Ashraf-Ganjouei
    • , Reza Assadi
    • , Bahar Ataeinia
    • , Sachin R. Atre
    • , Beatriz Paulina Ayala Quintanilla
    • , Martin Amogre Ayanore
    • , Samad Azari
    • , Ebrahim Babaee
    • , Arefeh Babazadeh
    • , Alaa Badawi
    • , Soghra Bagheri
    • , Mojtaba Bagherzadeh
    • , Nafiseh Baheiraei
    • , Abbas Balouchi
    • , Aleksandra Barac
    • , Quique Bassat
    • , Bernhard T. Baune
    • , Mohsen Bayati
    • , Neeraj Bedi
    • , Ettore Beghi
    • , Masoud Behzadifar
    • , Meysam Behzadifar
    • , Yared Belete Belay
    • , Brent Bell
    • , Michelle L. Bell
    • , Dessalegn Ajema Berbada
    • , Robert S. Bernstein
    • , Natalia V. Bhattacharjee
    • , Suraj Bhattarai
    • , Zulfiqar A. Bhutta
    • , Ali Bijani
    • , Somayeh Bohlouli
    • , Nicholas J. K. Breitborde
    • , Gabrielle Britton
    • , Annie J. Browne
    • , Sharath Burugina Nagaraja
    • , Reinhard Busse
    • , Zahid A. Butt
    • , Josip Car
    • , Rosario Cárdenas
    • , Carlos A. Castañeda-Orjuela
    • , Ester Cerin
    • , Wagaye Fentahun Chanie
    • , Pranab Chatterjee
    • , Dinh-Toi Chu
    • , Cyrus Cooper
    • , Vera M. Costa
    • , Koustuv Dalal
    • , Lalit Dandona
    • , Rakhi Dandona
    • , Farah Daoud
    • , Ahmad Daryani
    • , Rajat Das Gupta
    • , Ian Davis
    • , Nicole Davis Weaver
    • , Dragos Virgil Davitoiu
    • , Jan-Walter De Neve
    • , Feleke Mekonnen Demeke
    • , Gebre Teklemariam Demoz
    • , Kebede Deribe
    • , Rupak Desai
    • , Aniruddha Deshpande
    • , Hanna Demelash Desyibelew
    • , Sagnik Dey
    • , Samath Dhamminda Dharmaratne
    • , Meghnath Dhimal
    • , Daniel Diaz
    • , Leila Doshmangir
    • , Andre R. Duraes
    • , Laura Dwyer-Lindgren
    • , Lucas Earl
    • , Roya Ebrahimi
    • , Soheil Ebrahimpour
    • , Andem Effiong
    • , Aziz Eftekhari
    • , Elham Ehsani-Chimeh
    • , Iman El Sayed
    • , Maysaa El Sayed Zaki
    • , Maha El Tantawi
    • , Ziad El-Khatib
    • , Mohammad Hassan Emamian
    • , Shymaa Enany
    • , Sharareh Eskandarieh
    • , Oghenowede Eyawo
    • , Maha Ezalarab
    • , Mahbobeh Faramarzi
    • , Mohammad Fareed
    • , Roghiyeh Faridnia
    • , Andre Faro
    • , Ali Akbar Fazaeli
    • , Mehdi Fazlzadeh
    • , Netsanet Fentahun
    • , Seyed-Mohammad Fereshtehnejad
    • , João C. Fernandes
    • , Irina Filip
    • , Florian Fischer
    • , Nataliya A. Foigt
    • , Masoud Foroutan
    • , Joel Msafiri Francis
    • , Takeshi Fukumoto
    • , Nancy Fullman
    • , Silvano Gallus
    • , Destallem Gebremedhin Gebre
    • , Tsegaye Tewelde Gebrehiwot
    • , Gebreamlak Gebremedhn Gebremeskel
    • , Bradford D. Gessner
    • , Birhanu Geta
    • , Peter W. Gething
    • , Reza Ghadimi
    • , Keyghobad Ghadiri
    • , Mahsa Ghajarzadeh
    • , Ahmad Ghashghaee
    • , Paramjit Singh Gill
    • , Tiffany K. Gill
    • , Nick Golding
    • , Nelson G. M. Gomes
    • , Philimon N. Gona
    • , Sameer Vali Gopalani
    • , Giuseppe Gorini
    • , Bárbara Niegia Garcia Goulart
    • , Nicholas Graetz
    • , Felix Greaves
    • , Manfred S. Green
    • , Yuming Guo
    • , Arvin Haj-Mirzaian
    • , Arya Haj-Mirzaian
    • , Brian James Hall
    • , Samer Hamidi
    • , Hamidreza Haririan
    • , Josep Maria Haro
    • , Milad Hasankhani
    • , Edris Hasanpoor
    • , Amir Hasanzadeh
    • , Hadi Hassankhani
    • , Hamid Yimam Hassen
    • , Mohamed I. Hegazy
    • , Delia Hendrie
    • , Fatemeh Heydarpour
    • , Thomas R. Hird
    • , Chi Linh Hoang
    • , Gillian Hollerich
    • , Enayatollah Homaie Rad
    • , Mojtaba Hoseini-Ghahfarokhi
    • , Naznin Hossain
    • , Mostafa Hosseini
    • , Mehdi Hosseinzadeh
    • , Mihaela Hostiuc
    • , Sorin Hostiuc
    • , Mowafa Househ
    • , Mohamed Hsairi
    • , Olayinka Stephen Ilesanmi
    • , Mohammad Hasan Imani-Nasab
    • , Usman Iqbal
    • , Seyed Sina Naghibi Irvani
    • , Nazrul Islam
    • , Sheikh Mohammed Shariful Islam
    • , Mikk Jürisson
    • , Nader Jafari Balalami
    • , Amir Jalali
    • , Javad Javidnia
    • , Achala Upendra Jayatilleke
    • , Ensiyeh Jenabi
    • , John S. Ji
    • , Yash B. Jobanputra
    • , Kimberly Johnson
    • , Jost B. Jonas
    • , Zahra Jorjoran Shushtari
    • , Jacek Jerzy Jozwiak
    • , Ali Kabir
    • , Amaha Kahsay
    • , Hamed Kalani
    • , Rohollah Kalhor
    • , Manoochehr Karami
    • , Surendra Karki
    • , Amir Kasaeian
    • , Nicholas J. Kassebaum
    • , Peter Njenga Keiyoro
    • , Grant Rodgers Kemp
    • , Roghayeh Khabiri
    • , Yousef Saleh Khader
    • , Morteza Abdullatif Khafaie
    • , Ejaz Ahmad Khan
    • , Junaid Khan
    • , Muhammad Shahzeb Khan
    • , Young-Ho Khang
    • , Khaled Khatab
    • , Amir Khater
    • , Mona M. Khater
    • , Alireza Khatony
    • , Mohammad Khazaei
    • , Salman Khazaei
    • , Maryam Khazaei-Pool
    • , Jagdish Khubchandani
    • , Neda Kianipour
    • , Yun Jin Kim
    • , Ruth W. Kimokoti
    • , Damaris K. Kinyoki
    • , Adnan Kisa
    • , Sezer Kisa
    • , Tufa Kolola
    • , Soewarta Kosen
    • , Parvaiz A. Koul
    • , Ai Koyanagi
    • , Moritz U. G. Kraemer
    • , Kewal Krishan
    • , Kris J. Krohn
    • , Nuworza Kugbey
    • , G. Anil Kumar
    • , Manasi Kumar
    • , Pushpendra Kumar
    • , Desmond Kuupiel
    • , Ben Lacey
    • , Sheetal D. Lad
    • , Faris Hasan Lami
    • , Anders O. Larsson
    • , Paul H. Lee
    • , Mostafa Leili
    • , Aubrey J. Levine
    • , Shanshan Li
    • , Lee-Ling Lim
    • , Stefan Listl
    • , Joshua Longbottom
    • , Jaifred Christian F. Lopez
    • , Stefan Lorkowski
    • , Sameh Magdeldin
    • , Hassan Magdy Abd El Razek
    • , Muhammed Magdy Abd El Razek
    • , Azeem Majeed
    • , Afshin Maleki
    • , Reza Malekzadeh
    • , Deborah Carvalho Malta
    • , Abdullah A. Mamun
    • , Navid Manafi
    • , Ana-Laura Manda
    • , Morteza Mansourian
    • , Francisco Rogerlândio Martins-Melo
    • , Anthony Masaka
    • , Benjamin Ballard Massenburg
    • , Pallab K. Maulik
    • , Benjamin K. Mayala
    • , Mohsen Mazidi
    • , Martin McKee
    • , Ravi Mehrotra
    • , Kala M. Mehta
    • , Gebrekiros Gebremichael Meles
    • , Walter Mendoza
    • , Ritesh G. Menezes
    • , Atte Meretoja
    • , Tuomo J. Meretoja
    • , Tomislav Mestrovic
    • , Ted R. Miller
    • , Molly K. Miller-Petrie
    • , Edward J. Mills
    • , George J. Milne
    • , G. K. Mini
    • , Seyed Mostafa Mir
    • , Hamed Mirjalali
    • , Erkin M. Mirrakhimov
    • , Efat Mohamadi
    • , Dara K. Mohammad
    • , Aso Mohammad Darwesh
    • , Naser Mohammad Gholi Mezerji
    • , Ammas Siraj Mohammed
    • , Shafiu Mohammed
    • , Ali H. Mokdad
    • , Mariam Molokhia
    • , Lorenzo Monasta
    • , Yoshan Moodley
    • , Mahmood Moosazadeh
    • , Ghobad Moradi
    • , Masoud Moradi
    • , Yousef Moradi
    • , Maziar Moradi-Lakeh
    • , Mehdi Moradinazar
    • , Paula Moraga
    • , Lidia Morawska
    • , Abbas Mosapour
    • , Seyyed Meysam Mousavi
    • , Ulrich Otto Mueller
    • , Atalay Goshu Muluneh
    • , Ghulam Mustafa
    • , Behnam Nabavizadeh
    • , Mehdi Naderi
    • , Ahamarshan Jayaraman Nagarajan
    • , Azin Nahvijou
    • , Farid Najafi
    • , Vinay Nangia
    • , Duduzile Edith Ndwandwe
    • , Nahid Neamati
    • , Ionut Negoi
    • , Ruxandra Irina Negoi
    • , Josephine W. Ngunjiri
    • , Huong Lan Thi Nguyen
    • , Long Hoang Nguyen
    • , Son Hoang Nguyen
    • , Katie R. Nielsen
    • , Dina Nur Anggraini Ningrum
    • , Yirga Legesse Nirayo
    • , Molly R. Nixon
    • , Chukwudi A. Nnaji
    • , Marzieh Nojomi
    • , Mehdi Noroozi
    • , Shirin Nosratnejad
    • , Jean Jacques Noubiap
    • , Soraya Nouraei Motlagh
    • , Richard Ofori-Asenso
    • , Felix Akpojene Ogbo
    • , Kelechi E. Oladimeji
    • , Andrew T. Olagunju
    • , Meysam Olfatifar
    • , Solomon Olum
    • , Bolajoko Olubukunola Olusanya
    • , Mojisola Morenike Oluwasanu
    • , Obinna E. Onwujekwe
    • , Eyal Oren
    • , Doris D. V. Ortega-Altamirano
    • , Alberto Ortiz
    • , Osayomwanbo Osarenotor
    • , Frank B. Osei
    • , Aaron E. Osgood-Zimmerman
    • , Stanislav S. Otstavnov
    • , Mayowa Ojo Owolabi
    • , Mahesh P. A.
    • , Abdol Sattar Pagheh
    • , Smita Pakhale
    • , Songhomitra Panda-Jonas
    • , Animika Pandey
    • , Eun-Kee Park
    • , Hadi Parsian
    • , Tahereh Pashaei
    • , Sangram Kishor Patel
    • , Veincent Christian Filipino Pepito
    • , Alexandre Pereira
    • , Samantha Perkins
    • , Brandon V. Pickering
    • , Thomas Pilgrim
    • , Majid Pirestani
    • , Bakhtiar Piroozi
    • , Meghdad Pirsaheb
    • , Oleguer Plana-Ripoll
    • , Hadi Pourjafar
    • , Parul Puri
    • , Mostafa Qorbani
    • , Hedley Quintana
    • , Mohammad Rabiee
    • , Navid Rabiee
    • , Amir Radfar
    • , Alireza Rafiei
    • , Fakher Rahim
    • , Zohreh Rahimi
    • , Vafa Rahimi-Movaghar
    • , Shadi Rahimzadeh
    • , Fatemeh Rajati
    • , Sree Bhushan Raju
    • , Azra Ramezankhani
    • , Chhabi Lal Ranabhat
    • , Davide Rasella
    • , Vahid Rashedi
    • , Lal Rawal
    • , Robert C. Reiner Jr
    • , Andre M. N. Renzaho
    • , Satar Rezaei
    • , Aziz Rezapour
    • , Seyed Mohammad Riahi
    • , Ana Isabel Ribeiro
    • , Leonardo Roever
    • , Elias Merdassa Roro
    • , Max Roser
    • , Gholamreza Roshandel
    • , Daem Roshani
    • , Ali Rostami
    • , Enrico Rubagotti
    • , Salvatore Rubino
    • , Siamak Sabour
    • , Nafis Sadat
    • , Ehsan Sadeghi
    • , Reza Saeedi
    • , Yahya Safari
    • , Roya Safari-Faramani
    • , Mahdi Safdarian
    • , Amirhossein Sahebkar
    • , Mohammad Reza Salahshoor
    • , Nasir Salam
    • , Payman Salamati
    • , Farkhonde Salehi
    • , Saleh Salehi Zahabi
    • , Yahya Salimi
    • , Hamideh Salimzadeh
    • , Joshua A. Salomon
    • , Evanson Zondani Sambala
    • , Abdallah M. Samy
    • , Milena M. Santric Milicevic
    • , Bruno Piassi Sao Jose
    • , Sivan Yegnanarayana Iyer Saraswathy
    • , Rodrigo Sarmiento-Suárez
    • , Benn Sartorius
    • , Brijesh Sathian
    • , Sonia Saxena
    • , Alyssa N. Sbarra
    • , Lauren E. Schaeffer
    • , David C. Schwebel
    • , Sadaf G. Sepanlou
    • , Seyedmojtaba Seyedmousavi
    • , Faramarz Shaahmadi
    • , Masood Ali Shaikh
    • , Mehran Shams-Beyranvand
    • , Amir Shamshirian
    • , Morteza Shamsizadeh
    • , Kiomars Sharafi
    • , Mehdi Sharif
    • , Mahdi Sharif-Alhoseini
    • , Hamid Sharifi
    • , Jayendra Sharma
    • , Rajesh Sharma
    • , Aziz Sheikh
    • , Chloe Shields
    • , Mika Shigematsu
    • , Rahman Shiri
    • , Ivy Shiue
    • , Kerem Shuval
    • , Tariq J. Siddiqi
    • , João Pedro Silva
    • , Jasvinder A. Singh
    • , Dhirendra Narain Sinha
    • , Malede Mequanent Sisay
    • , Solomon Sisay
    • , Karen Sliwa
    • , David L. Smith
    • , Ranjani Somayaji
    • , Moslem Soofi
    • , Joan B. Soriano
    • , Chandrashekhar T. Sreeramareddy
    • , Agus Sudaryanto
    • , Mu’awiyyah Babale Sufiyan
    • , Bryan L. Sykes
    • , P. N. Sylaja
    • , Rafael Tabarés-Seisdedos
    • , Karen M. Tabb
    • , Takahiro Tabuchi
    • , Nuno Taveira
    • , Mohamad-Hani Temsah
    • , Abdullah Sulieman Terkawi
    • , Zemenu Tadesse Tessema
    • , Kavumpurathu Raman Thankappan
    • , Sathish Thirunavukkarasu
    • , Quyen G. To
    • , Marcos Roberto Tovani-Palone
    • , Bach Xuan Tran
    • , Khanh Bao Tran
    • , Irfan Ullah
    • , Muhammad Shariq Usman
    • , Olalekan A. Uthman
    • , Amir Vahedian-Azimi
    • , Pascual R. Valdez
    • , Job F. M. van Boven
    • , Tommi Juhani Vasankari
    • , Yasser Vasseghian
    • , Yousef Veisani
    • , Narayanaswamy Venketasubramanian
    • , Francesco S. Violante
    • , Sergey Konstantinovitch Vladimirov
    • , Vasily Vlassov
    • , Theo Vos
    • , Giang Thu Vu
    • , Isidora S. Vujcic
    • , Yasir Waheed
    • , Jon Wakefield
    • , Haidong Wang
    • , Yafeng Wang
    • , Yuan-Pang Wang
    • , Joseph L. Ward
    • , Robert G. Weintraub
    • , Kidu Gidey Weldegwergs
    • , Girmay Teklay Weldesamuel
    • , Ronny Westerman
    • , Charles Shey Wiysonge
    • , Dawit Zewdu Wondafrash
    • , Lauren Woyczynski
    • , Ai-Min Wu
    • , Gelin Xu
    • , Abbas Yadegar
    • , Tomohide Yamada
    • , Vahid Yazdi-Feyzabadi
    • , Christopher Sabo Yilgwan
    • , Paul Yip
    • , Naohiro Yonemoto
    • , Javad Yoosefi Lebni
    • , Mustafa Z. Younis
    • , Mahmoud Yousefifard
    • , Hebat-Allah Salah A. Yousof
    • , Chuanhua Yu
    • , Hasan Yusefzadeh
    • , Erfan Zabeh
    • , Telma Zahirian Moghadam
    • , Sojib Bin Zaman
    • , Mohammad Zamani
    • , Hamed Zandian
    • , Alireza Zangeneh
    • , Taddese Alemu Zerfu
    • , Yunquan Zhang
    • , Arash Ziapour
    • , Sanjay Zodpey
    • , Christopher J. L. Murray
    •  & Simon I. Hay
  • Letter |

    Widespread formation of new particles from condensable vapours observed in the tropical upper troposphere is an important source of cloud condensation nuclei in the lower troposphere, affecting cloud properties.

    • Christina J. Williamson
    • , Agnieszka Kupc
    • , Duncan Axisa
    • , Kelsey R. Bilsback
    • , ThaoPaul Bui
    • , Pedro Campuzano-Jost
    • , Maximilian Dollner
    • , Karl D. Froyd
    • , Anna L. Hodshire
    • , Jose L. Jimenez
    • , John K. Kodros
    • , Gan Luo
    • , Daniel M. Murphy
    • , Benjamin A. Nault
    • , Eric A. Ray
    • , Bernadett Weinzierl
    • , James C. Wilson
    • , Fangqun Yu
    • , Pengfei Yu
    • , Jeffrey R. Pierce
    •  & Charles A. Brock
  • Letter |

    Three-dimensional gas velocities in the gapped disk around the young star HD 163296 show meridional flows from the surface of the disk towards its midplane at gap locations.

    • Richard Teague
    • , Jaehan Bae
    •  & Edwin A. Bergin

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