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| Open AccessNMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γ
- Phillip C. Aoto
- , Bryan T. Martin
- & Peter E. Wright
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Article
| Open AccessIdentifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry
- André C. Müller
- , Roberto Giambruno
- & Keiryn L. Bennett
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Article
| Open AccessOncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
- David S. Moura
- , Isabel F. Fernández
- & Pedro A. Lazo
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Article
| Open AccessA new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation
- Qiang Wei
- , Shaoyuan Yang
- & Zongchao Jia
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Article
| Open AccessAnalysis of crystal structure of Arabidopsis MPK6 and generation of its mutants with higher activity
- Bo Wang
- , Xinghua Qin
- & Dongtao Ren
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Article
| Open AccessA platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors
- Yuming Wei
- , Daniel C. Poon
- & Kenneth K. W. To
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Article
| Open Access3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling
- Ke-ran Li
- , Su-qing Yang
- & Cong Cao
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Article
| Open AccessCharacterization of a temperature-responsive two component regulatory system from the Antarctic archaeon, Methanococcoides burtonii
- T. Najnin
- , K. S. Siddiqui
- & R. Cavicchioli
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Article
| Open AccessOptogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors
- Claire V. Chatelle
- , Désirée Hövermann
- & Gerald Radziwill
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Article
| Open AccessInhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats
- Cheng-long Xie
- , Jing-Ya Lin
- & Zhen-Guo Liu
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Article
| Open AccessTestis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76
- Xiaoli Wang
- , Han Li
- & Shi Chen
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Article
| Open AccessStructure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus – Insights into a novel pro-drug approach addressing MRSA infections
- Julia Drebes
- , Madeleine Künz
- & Carsten Wrenger
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Article
| Open AccessMASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
- Po Yee Wong
- , Hoi Tang Ma
- & Randy Y. C. Poon
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Article
| Open AccessRational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes
- Darlene Aparecida Pena
- , Victor Piana de Andrade
- & Deborah Schechtman
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Article
| Open AccessResveratrol induces autophagy by directly inhibiting mTOR through ATP competition
- Dohyun Park
- , Heeyoon Jeong
- & Sung Ho Ryu
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Article
| Open AccessAutophosphorylation at Thr279 of Entamoeba histolytica atypical kinase EhAK1 is required for activity and regulation of erythrophagocytosis
- M Shahid Mansuri
- , Mrigya Babuta
- & Alok Bhattacharya
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Article
| Open AccessICE1 of Pyrus ussuriensis functions in cold tolerance by enhancing PuDREBa transcriptional levels through interacting with PuHHP1
- Xiaosan Huang
- , Kongqing Li
- & Shaoling Zhang
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Article
| Open AccessThe structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase
- Ali Flayhan
- , Célia Bergé
- & Laurent Terradot
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Article
| Open AccessUrsolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells
- Seong-Hoon Kim
- , Hye Guk Ryu
- & Kyong-Tai Kim
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Article
| Open AccessAutophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder
- John W. Scott
- , Elizabeth Park
- & Bruce E. Kemp
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Article
| Open AccessGene looping facilitates TFIIH kinase-mediated termination of transcription
- Scott Medler
- & Athar Ansari
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Article
| Open AccessIdentification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ
- Rie Sonamoto
- , Isao Kii
- & Masatoshi Hagiwara
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Article
| Open AccessPolyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation
- I-Ting Chen
- , Pang-Hung Hsu
- & Ping-Hui Tseng
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| Open AccessIn-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs
- Ruth Röck
- , Verena Bachmann
- & Eduard Stefan
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Article
| Open AccessFunctional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases
- Lun Zhang
- , Jian-Chuan Wang
- & Jia Li
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Article
| Open AccessDesign, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
- Rubén Ferreira
- , Jesper R. Nilsson
- & Morten Grøtli
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Article
| Open AccessTruncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease
- Nana Jin
- , Xiaomin Yin
- & Fei Liu
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Article
| Open AccessCapsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2
- Sung Un Huh
- , Gil-Je Lee
- & Kyung-Hee Paek
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Article
| Open AccessElucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice
- Lillia V. Ryazanova
- , Zhixian Hu
- & Alexey G. Ryazanov
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Article
| Open AccessAnthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock
- Karothu Durga Prasad
- , Jamma Trinath
- & Tayur N. Guru Row
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Article
| Open AccessInactivation of TRPM7 kinase activity does not impair its channel function in mice
- Taku Kaitsuka
- , Chiaki Katagiri
- & Masayuki Matsushita
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Article
| Open AccessScreening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells
- Vehary Sakanyan
- , Marie Angelini
- & Fabrice Fleury
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Article
| Open AccessJAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations
- Yuan Ren
- , Yonghong Zhang
- & Jie Wu
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Article
| Open AccessConferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase
- Yusuke Nakamichi
- , Aya Yoshioka
- & Kousaku Murata
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Article
| Open AccessInvolvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway
- Noritaka Yamaguchi
- , Masaaki Oyama
- & Jun-ichiro Inoue
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Article
| Open AccessSprouty genes regulate proliferation and survival of human embryonic stem cells
- Hady Felfly
- & Ophir D. Klein
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Article
| Open AccessMetformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- Barbara Salani
- , Cecilia Marini
- & Gianmario Sambuceti
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| Open AccessDual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity
- Duanwen Shen
- , Mingfeng Bai
- & Samuel Achilefu
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Article
| Open AccessBacterial expression strategies for several Sus scrofa diacylglycerol kinase alpha constructs: solubility challenges
- Elizabeth J. Petro
- & Daniel M. Raben
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Article
| Open AccessPMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H1 receptor
- Hiroyuki Mizuguchi
- , Kohei Miyagi
- & Hiroyuki Fukui
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| Open AccessGTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1
- Joseph D. Jebelli
- , Sybille Dihanich
- & Patrick A. Lewis