Featured
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Cash crisis looms for vaccine drive
Rising demand for immunization programmes in developing countries could outstrip funding.
- Declan Butler
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News |
A direct hit for thalidomide
The drug stunts limb development in zebrafish and chicks by binding to a protein called cereblon.
- Janet Fang
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Letter |
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
In a mouse model of prostate cancer it is shown that infiltrating B cells promote tumorigenesis by secreting lymphotoxin. Lymphotoxin accelerates the emergence of castration-resistant prostate tumours in this model. Interfering with this pathway may offer therapeutic strategies for androgen-independent prostate cancer.
- Massimo Ammirante
- , Jun-Li Luo
- & Michael Karin
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News |
Blame it on the B cells
Immune cells seem to spark recurrent prostate cancer in mice.
- Brian Vastag
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News |
Hiding place for HIV revealed
The AIDS virus escapes treatment inside progenitor blood cells.
- Janet Fang
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News |
Tough lessons from Dutch Q fever outbreak
Mass cull of goats questioned as researchers race to find strain behind human cases.
- Naomi Lubick
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Research Highlights |
Molecular imaging: Tumour glows out
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Opinion |
Globe still in grip of addiction
After five years, the World Health Organization's tobacco-control treaty is starting to have an effect, but we need to tackle the smoking epidemic in the developing world, say Jonathan M. Samet and Heather L. Wipfli.
- Jonathan M. Samet
- & Heather L. Wipfli
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News |
'Seek, test and treat' slows HIV
Studies in several nations show that treating people before they fall ill can curb the spread of disease.
- Erika Check Hayden
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Research Highlights |
Genetics: Two strikes
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Technology Feature |
Probe progress
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News |
Hopes grow over potential autism treatment
Oxytocin hormone shown to improve social interaction.
- Daniel Cressey
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News |
Medical isotope supplies dwindle
Nuclear-reactor shutdowns will cripple global isotope production next month.
- Paula Gould
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Brief Communications Arising |
Chronic DLL4 blockade induces vascular neoplasms
- Minhong Yan
- , Christopher A. Callahan
- & Greg D. Plowman
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Opinion |
AIDS research must link to local policy
HIV research in South Africa is world class. To halt the country's epidemic, scientists need to shift focus from global problems to priorities at home, say Salim Abdool Karim and Quarraisha Abdool Karim.
- Salim S. Abdool Karim
- & Quarraisha Abdool Karim
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News |
Changes proposed to key psychiatry manual
Controversial revision alters diagnostic definitions.
- Heidi Ledford
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News |
Untangling HIV transmission in men
Study could put scientists on the right path to blocking the spread of new infections.
- Erika Check Hayden
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Books & Arts |
The woman behind HeLa
Steve Silberman enjoys a moving account that probes racial and ethical issues in medicine through the story of the young mother whose death from cancer led to the first immortal cell line.
- Steve Silberman
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News & Views |
Big roles for small RNAs
Embryonic stem cells can create copies of themselves, but can also mature into almost any type of cell in the body. Tiny gene regulators called microRNAs are now shown to have a role in directing these properties.
- Frank J. Slack
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Brain scan allows unconscious patient to communicate
Imaging technique pierces vegetative state.
- Heidi Ledford
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News |
Cot death victims make less serotonin
Mysterious infant deaths linked to chemical deficiency.
- Heidi Ledford
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News |
Ten billion dollars pledged for 'decade of vaccines'
Gates Foundation cash could save nearly nine million children.
- Heidi Ledford
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Editorial |
Learning to share
By opening up its database of potential malaria drugs, GlaxoSmithKline has blazed a path that other pharmaceutical companies should follow.
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News & Views |
50 & 100 years ago
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Research Highlights |
Vascular biology: Hearty hormones
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Research Highlights |
Regenerative biology: New nerve cells connect
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News & Views |
Stability in times of stress
Damaged lysosomes, the principal degradative organelles, can kill a cell. A stress-induced protein controls lysosome stability, providing a potential target to treat lysosome-related diseases and cancer.
- Ibolya Horváth
- & László Vígh
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Aid fund faces cash crunch
Fight against tuberculosis, malaria and AIDS under threat from success.
- Declan Butler
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Head of German drug agency to leave post
Board calls time on embattled director of pharmaceutical evaluation institute.
- Quirin Schiermeier
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News |
Lawsuit rekindles gene-patent debate
Criticism of exclusive licences puts university policies in the spotlight.
- Brendan Borrell
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News |
Superbug family tree sketched out
Next-generation genome sequencing enables detailed tracking of MRSA infections.
- Lucas Laursen
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Research Highlights |
Evolutionary biology: Sperm signals
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Research Highlights |
Neuropharmacology: Beating depression
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Books & Arts |
Vision of a personal genomics future
The director of the US National Institutes of Health, Francis Collins, calls for a revolution in personalized medicine. Such advances should be shared beyond the developed world, says Abdallah S. Daar.
- Abdallah S. Daar
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News |
Geologists to evaluate future Haiti risks
Hunt for survey markers may reveal crucial data.
- Rex Dalton
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Editorial |
Lessons from a pandemic
It is time to assess what worked, and what didn't, in the global efforts to cope with swine flu.
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News Feature |
Neuroscience: The most vulnerable brains
An increase in premature births means that more babies are at risk of neurological damage. Erika Check Hayden talks with researchers who are developing ways to help these children.
- Erika Check Hayden
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Streamlined chemical tests rebuffed
Europe impedes introduction of REACH safety assessments.
- Natasha Gilbert
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News Feature |
Swine flu: Crisis communicator
Richard Besser led the United States' top public-health agency as swine flu broke out on its doorstep. And his communication shaped the early days of a pandemic, finds Brendan Maher.
- Brendan Maher
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Article |
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
GNF-2 is a recently discovered, selective allosteric Bcr–Abl inhibitor. Solution NMR, X-ray crystallography, mutagenesis and hydrogen exchange mass spectrometry are now used to show that GNF-2 binds to the myristate-binding site of Abl, leading to changes in the structural dynamics of the ATP-binding site. The results show that the combination of allosteric and ATP-competitive inhibitors can overcome resistance to either agent alone.
- Jianming Zhang
- , Francisco J. Adrián
- & Nathanael S. Gray
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News |
Driveways could spread toxins into the home
Carcinogens in coal tar–sealed pavements cause worry.
- Nicola Jones
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Opinion |
2020 visions
For the first issue of the new decade, Nature asked a selection of leading researchers and policy-makers where their fields will be ten years from now. We invited them to identify the key questions their disciplines face, the major roadblocks and the pressing next steps.