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Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ
A biosensor comprising bacteria engineered to respond to transient inflammatory signals has been packaged with electronic readout and transmission circuits in a small device that could be swallowed to monitor gastrointestinal health.
- M. E. Inda-Webb
- , M. Jimenez
- & T. K. Lu
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Article |
AI-based pathology predicts origins for cancers of unknown primary
A deep-learning-based algorithm uses routinely acquired histology slides to provide a differential diagnosis for the origin of the primary tumour for complicated cases of metastatic tumours and cancers of unknown primary origin.
- Ming Y. Lu
- , Tiffany Y. Chen
- & Faisal Mahmood
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Review Article |
Taking connected mobile-health diagnostics of infectious diseases to the field
Combining mobile phone technologies with infectious disease diagnostics can increase patients’ access to testing and treatment and provide public health authorities with new ways to monitor and control outbreaks of infectious diseases.
- Christopher S. Wood
- , Michael R. Thomas
- & Molly M. Stevens
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Letter |
Dermatologist-level classification of skin cancer with deep neural networks
An artificial intelligence trained to classify images of skin lesions as benign lesions or malignant skin cancers achieves the accuracy of board-certified dermatologists.
- Andre Esteva
- , Brett Kuprel
- & Sebastian Thrun
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Outlook |
Neurobiology: Unrestrained excitement
Epilepsy arises from natural mechanisms in the brain that go awry. Researchers are trying to unravel its complexities.
- Michael Eisenstein
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Outlook |
Diagnostics: Detection drives defence
Devices that quickly identify bacterial infections would benefit health and slow the spread of resistance.
- Rebecca Kanthor
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Outlook |
Software: The computer will see you now
From image-analysis software to lens-free microscopes that fit on a mobile phone, new tools are providing pathologists with clearer and more informative images.
- Katherine Bourzac
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News |
Brain cells made from urine
Human excreta could be a powerful source of cells to study disease, bypassing some of the problems of using stem cells.
- Monya Baker
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Outlook |
Diagnostics: Playing detective
Physical scientists are developing tools to spot cancer earlier.
- Cassandra Willyard
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Comment |
Politics and fetal diagnostics collide
Without better regulation, non-invasive prenatal genetic tests will be targeted by US anti-abortion lobbyists, argues Jaime S. King.
- Jaime S. King
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Outlook |
Diagnosis: Redefining autism
Draft diagnostic guidelines are raising concerns that mild forms of the disorder may no longer be recognized.
- Emily Singer
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News |
Disrupted sleep may predict Alzheimer’s
Poor sleep patterns linked to formation of Alzheimer's plaques.
- Mo Costandi
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Outlook |
Diagnosis: To catch a killer
The first symptoms of COPD can be subtle, so the disease often goes undiagnosed. Researchers are searching for ways to detect the disease and to identify those most at risk.
- Cassandra Willyard
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Outlook |
Health impact: Breathless
COPD is one of the world's biggest killers, but awareness is low, diagnosis is often missed, and in many countries the extent of the problem is not even well-documented.
- Amber Dance
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News |
Rabbits show their pain
The extension of 'grimace scales' highlights their growing role in research.
- Daniel Cressey
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Outlook |
Screening: Testing times
Pap tests have been a mainstay of cervical cancer screening, but new tests, vaccines and knowledge might be changing that, including when and how frequently to test.
- Courtney Humphries
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News |
Ebola outbreak tests local surveillance
Ugandan laboratory helps to minimize number of cases.
- Ewen Callaway
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News & Views |
Fetal genes in mother's blood
The genome sequence of a fetus can be inferred from the relative numbers of variants of DNA sequences in a pregnant woman's blood. This advance in non-invasive diagnostics comes with some ramifications. See Article p.320
- Diana W. Bianchi
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Article |
Non-invasive prenatal measurement of the fetal genome
Prenatal testing usually requires invasive sampling; here molecular counting of parental haplotypes in the maternal plasma allows the fetal genome to be deciphered and molecular counting of individual alleles enables the fetal exome to be captured.
- H. Christina Fan
- , Wei Gu
- & Stephen R. Quake
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News & Views |
Pinprick diagnostics
Rare tumour cells with mutations that confer drug resistance can go undetected by standard testing procedures, according to two studies, which show that such mutations can be detected in patients' blood. See Letters p.532 and p.537
- Eduardo Vilar
- & Josep Tabernero
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News |
Fetal tests spur legal battle
A newborn industry based on non-invasive genetic testing turns combative.
- Erika Check Hayden
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Research Highlights |
Sequencing tracks outbreak
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News |
Genome test slammed for assessing ‘racial purity’
Hungarian far-right politician certified as ‘free of Jewish and Roma’ genes.
- Alison Abbott
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Research Highlights |
Sequencing spots tumour cells
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News |
Psychosis risk syndrome excluded from DSM-5
Benefits of catching psychosis early are deemed to come at too high a price.
- Amy Maxmen
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News |
Drug-resistant bacteria go undetected
Poor training in use of tests allows ‘superbugs’ to evade surveillance.
- Daniel Cressey
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News |
Gene hunt is on for mental disability
Pioneering clinical genome-sequencing projects focus on patients with developmental delay.
- Ewen Callaway
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Outlook |
Diagnostics: Getting a clear picture
Technologies that better reveal the insidious progression of multiple sclerosis could aid the search for treatments.
- Cynthia Graber
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Letter |
Wild-type microglia arrest pathology in a mouse model of Rett syndrome
Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.
- Noël C. Derecki
- , James C. Cronk
- & Jonathan Kipnis
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News |
Industry ties remain rife on panels for psychiatry manual
Review identifies potential conflicts of interest among those drawing up DSM-5.
- Heidi Ledford
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News Feature |
Rare diseases: Genomics, plain and simple
A Pennsylvania clinic working with Amish and Mennonite communities could be a model for personalized medicine.
- Trisha Gura
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News |
Sequencing set to alter clinical landscape
Access to whole genomes shifts potential for diagnosis, but poses challenges for doctors and regulators.
- Erika Check Hayden
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Letter |
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.
- Steven Z. Josefowicz
- , Rachel E. Niec
- & Alexander Y. Rudensky
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Research Highlights |
Sequencing diagnoses disease
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News |
Diagnostics tome comes under fire
Field tests of new criteria are flawed, critics argue.
- Heidi Ledford
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News |
Alzheimer's 'in a dish' shows promise
Reprogrammed cells suggest path towards early diagnosis and drug development.
- Ewen Callaway
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News |
Fears grow over lab-bred flu
Scientists call for stricter biosafety measures for dangerous avian-influenza variants.
- Declan Butler
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Brief Communications Arising |
Phiel et al. reply
- Christopher J. Phiel
- , Christina A. Wilson
- & Peter S. Klein
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Brief Communications Arising |
GSK-3α/β kinases and amyloid production in vivo
- Tomasz Jaworski
- , Ilse Dewachter
- & Fred Van Leuven
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Article |
Mutations causing syndromic autism define an axis of synaptic pathophysiology
The mutations that underlie the diseases tuberous sclerosis complex and fragile X syndrome produce abnormalities in synaptic plasticity and function that can be corrected by treatments that modulate metabotropic glutamate receptor 5 in opposite directions.
- Benjamin D. Auerbach
- , Emily K. Osterweil
- & Mark F. Bear
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News |
The computer will see you now
‘Computational pathologist’ diagnoses different grades of breast cancer.
- Heidi Ledford
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News Feature |
Special issue on neuroscience: The autism enigma
Diagnoses and research funding are rising, but much about autism remains a puzzle. Nature seeks some truths.
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News |
Nature readers flirt with personal genomics
Survey reveals eagerness to use latest DNA technologies.
- Brendan Maher
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Q&A |
Turning point: Rossa Chiu
Chemical pathologist makes breakthroughs in fetal-disease diagnostics.
- Virginia Gewin
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News |
Germany learns from E. coli outbreak
Government plans to upgrade its disease-reporting processes.
- Marian Turner
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News |
Urine predicts prostate cancer risk
Test could reduce unnecessary needle biopsies.
- Virginia Gewin
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Editorial |
There will be blood
Screening of newborns for genetic disorders is important, but so is educating parents to ensure that they give the proper consent.
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Outlook |
Perspective: Prevention is better than cure
Attempts to reduce amyloid-β in the brain have yet to show clinical benefits. Starting treatment early is the best hope, says Sam Gandy
- Sam Gandy
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News Feature |
Newborn screening: A spot of trouble
By raising hell about newborn blood-spot screening, Twila Brase could jeopardize public-health programmes and derail research. The problem is, she has a point.
- Mary Carmichael