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| Open AccessCytotoxic and antiviral activities of Jatropha variegata and Jatropha spinosa in relation to their metabolite profile
- Khawlah Shari
- , Osama G. Mohamed
- & Rania A. El Gedaily
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Article
| Open AccessMachine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors
- Sunil Kumar
- , Ratul Bhowmik
- & Bijo Mathew
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| Open AccessApomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors
- Akihiko Miyauchi
- , Chika Watanabe
- & Hitoshi Osaka
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| Open AccessMortality after major bleeding in Asian atrial fibrillation patients receiving different direct oral anticoagulants: a nationwide, propensity score study
- Jiun-Hao Yu
- , Pei-Ru Li
- & Lai-Chu See
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Article
| Open AccessSpray-dried pH-sensitive chitosan microparticles loaded with Mycobacterium bovis BCG intended for supporting treatment of Helicobacter pylori infection
- Weronika Gonciarz
- , Marek Brzeziński
- & Magdalena Chmiela
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| Open AccessStudy of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway
- Chunyu Chen
- , Xiaoxing Liu
- & Fan Yi
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| Open AccessRestoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
- Hsiang-Yu Chang
- & I-Fan Wang
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Article
| Open AccessStructure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)
- Sihui Chen
- , Chunhuan Jin
- & Yoshikatsu Kanai
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Article
| Open AccessNovel antimicrobial peptides against Cutibacterium acnes designed by deep learning
- Qichang Dong
- , Shaohua Wang
- & Lun Yu
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| Open AccessKinetic characterization of human mRNA guanine-N7 methyltransferase
- Sumera Perveen
- , Aliakbar Khalili Yazdi
- & Masoud Vedadi
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Article
| Open AccessA bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity
- Dareen Mikheil
- , Matthew A. Larsen
- & Said A. Goueli
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Article
| Open AccessAntioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic
- Érica Mendes dos Santos
- , Lucas Malvezzi de Macedo
- & Priscila Gava Mazzola
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Article
| Open AccessPredicting the formation of NADES using a transformer-based model
- Lucas B. Ayres
- , Federico J. V. Gomez
- & Carlos D. Garcia
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Article
| Open AccessRepeated microdoses of LSD do not alter anxiety or boldness in zebrafish
- Ethan V. Hagen
- , Melike Schalomon
- & Trevor J. Hamilton
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Article
| Open AccessNetwork analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetes
- Dicson Sheeja Malar
- , Kanika Verma
- & James Michael Brimson
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| Open AccessHepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
- Se-Myo Park
- , Mi-Sun Choi
- & Jung-Hwa Oh
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Article
| Open AccessModeling dry eye with an air–liquid interface in corneal epithelium-on-a-chip
- Rodi Kado Abdalkader
- , Romanas Chaleckis
- & Ken-ichiro Kamei
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Article
| Open AccessMultimodal CNN-DDI: using multimodal CNN for drug to drug interaction associated events
- Muhammad Asfand-e-yar
- , Qadeer Hashir
- & Waqar Khalil
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| Open AccessCombined substituent number utilized machine learning for the development of antimicrobial agent
- Keitaro Yamauchi
- , Hirotaka Nakatsuji
- & Hitoshi Kasai
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| Open AccessTargeting host-virus interactions: in silico analysis of the binding of human milk oligosaccharides to viral proteins involved in respiratory infections
- Anees Ahmed Mahaboob Ali
- , Adarsh Vishal
- & Everette Jacob Remington Nelson
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Article
| Open AccessProcess optimization for green synthesis of silver nanoparticles using Rubus discolor leaves extract and its biological activities against multi-drug resistant bacteria and cancer cells
- Saeed Ghasemi
- , Sara Dabirian
- & Fatemeh Yousefbeyk
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| Open AccessTargeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
- Henri Colyn Bwanika
- , Isabelle Rose Leo
- & Katja Pokrovskaja Tamm
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Article
| Open AccessToxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage
- Tingyue Wu
- , Wenjing Liu
- & Ceshi Chen
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Article
| Open AccessCarbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant
- Samar M. Mahgoub
- , Doaa Essam
- & Rehab Mahmoud
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| Open AccessProlyl hydroxylase domain inhibitor is an effective pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock
- Xiaowu Wu
- , Andrew P. Cap
- & Michael A. Meledeo
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Article
| Open AccessKaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats
- Akindele Oluwatosin Adeyi
- , Babafemi Siji Ajisebiola
- & Olukunle Silas Fagbenro
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| Open AccessHIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process
- Sijia Ma
- , Jia Wang
- & Le Zhao
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| Open AccessHigh-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair
- Saurabh S. Dhakar
- , Albert Galera-Prat
- & Lari Lehtiö
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Article
| Open AccessRipa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma
- Lemeng Feng
- , Shirui Dai
- & Weitao Song
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Article
| Open Access1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene
- Khaled Benchoula
- , Christopher J. Serpell
- & Wong Eng Hwa
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Article
| Open AccessPotential Alzheimer’s early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology
- Charles H. Wallace
- , Giovanni Oliveros
- & Maria Figueiredo-Pereira
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| Open AccessProtracted molecular dynamics and secondary structure introspection to identify dual-target inhibitors of Nipah virus exerting approved small molecules repurposing
- Siyun Yang
- & Supratik Kar
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| Open AccessFMO-guided design of darunavir analogs as HIV-1 protease inhibitors
- Hathaichanok Chuntakaruk
- , Kowit Hengphasatporn
- & Supot Hannongbua
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Article
| Open AccessRevealing the pharmacological effects of Remodelin against osteosarcoma based on network pharmacology, acRIP-seq and experimental validation
- Jia Gao
- , Peili Xu
- & Lei Fan
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| Open AccessEvaluation of the antidermatophytic activity of potassium salts of N-acylhydrazinecarbodithioates and their aminotriazole-thione derivatives
- Anita Ciesielska
- , Aleksandra Kowalczyk
- & Paweł Stączek
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Article
| Open AccessClinical trials are becoming more complex: a machine learning analysis of data from over 16,000 trials
- Nigel Markey
- , Ben Howitt
- & Christoph Meier
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| Open AccessLytic activity of phages against bacterial pathogens infecting diabetic foot ulcers
- Legesse Garedew Kifelew
- , Morgyn S. Warner
- & Peter G. Speck
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| Open AccessStructure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling
- Ahmed Abdullah Ahmed
- , Shuang Chen
- & Stephen Neidle
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Article
| Open AccessSynthesis, molecular docking and DFT analysis of novel bis-Schiff base derivatives with thiobarbituric acid for α-glucosidase inhibition assessment
- Saba Gul
- , Faheem Jan
- & Li Bo
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Article
| Open AccessFacilitating long-term cell examinations and time-lapse recordings in cell biology research with CO2 mini-incubators
- Ali Talebipour
- , Mehrdad Saviz
- & Reza Faraji-Dana
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| Open AccessDevelopment of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes
- Hiroki Sakamoto
- , Momoyo Nishikawa
- & Seigo Yamada
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Article
| Open AccessIdentification of potential inhibitor against Leishmania donovani mitochondrial DNA primase through in-silico and in vitro drug repurposing approaches
- Mitul Nath
- , Deep Bhowmik
- & Diwakar Kumar
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Article
| Open AccessIndole-3-carbinol (I3C) reduces apoptosis and improves neurological function after cerebral ischemia–reperfusion injury by modulating microglia inflammation
- Long Peng
- , Xingjia Zhu
- & Peipei Gong
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| Open AccessPsychedelics and sexual functioning: a mixed-methods study
- Tommaso Barba
- , Hannes Kettner
- & Bruna Giribaldi
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| Open AccessFunctional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study
- Sophia Armand
- , Christelle Langley
- & Patrick MacDonald Fisher
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Article
| Open AccessMetabolite profiling and in-silico studies show multiple effects of insecticidal actinobacterium on Spodoptera littoralis
- Mohamed Khaled Diab
- , Hala Mohamed Mead
- & Sahar Ahmed El-Shatoury
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| Open AccessTargeting the receptor binding domain and heparan sulfate binding for antiviral drug development against SARS-CoV-2 variants
- Zi-Sin Yang
- , Tzong-Shiun Li
- & Ching-Ming Chien
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Article
| Open AccessRegulation of the antibiotic elution profile from tricalcium phosphate bone cement by addition of bioactive glass
- H. K. Abd El-Hamid
- , Mohammad M. Farag
- & R. L. Elwan
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| Open AccessKnockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment
- Noreen Halimani
- , Mikhail Nesterchuk
- & Yuri V. Kotelevtsev