Brief Communications Arising |
Featured
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Brief Communications Arising |
Essentiality of FASII pathway for Staphylococcus aureus
- Wendy Balemans
- , Nacer Lounis
- & Anil Koul
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News |
NIH scrutinizes drug-company payments at Baylor
Funding agency raises 'serious concerns' about conflicts of interest.
- Brendan Borrell
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Letter |
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
High mutation rates in the influenza A virus facilitate the generation of viral escape mutants, rendering vaccines and drugs potentially ineffective, but targeting host cell determinants could prevent viral escape. Here, 287 human host cell genes influencing influenza A virus replication are found using a genome-wide RNA interference screen. An independent assay is then used to investigate overlap between genes necessary for different viral strains.
- Alexander Karlas
- , Nikolaus Machuy
- & Thomas F. Meyer
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Research Highlights |
Drug discovery: Virtual antibiotic screen
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News |
Streamlined chemical tests rebuffed
Europe impedes introduction of REACH safety assessments.
- Natasha Gilbert
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Letter |
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
G-protein-coupled receptors (GPCRs) mediate the majority of cellular responses to hormones and neurotransmitters and are the largest group of therapeutic targets for a range of diseases. The extracellular surface (ECS) of GPCRs is diverse and therefore an ideal target for the discovery of subtype-selective drugs. Here, NMR spectroscopy is used to investigate ligand-specific conformational changes around a central structural feature in the ECS of a GPCR.
- Michael P. Bokoch
- , Yaozhong Zou
- & Brian K. Kobilka