Article
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Open Access
Featured
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Article |
Targeting Xist with compounds that disrupt RNA structure and X inactivation
A molecule identified in a screen for compounds that bind the non-coding mouse RNA Xist blocks Xist-dependent X-chromosome inactivation, demonstrating the utility of this approach for identifying drugs that target RNA.
- Rodrigo Aguilar
- , Kerrie B. Spencer
- & Jeannie T. Lee
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Review Article |
Multispecific drugs herald a new era of biopharmaceutical innovation
The development and future prospects of prospectively designed multispecific drugs, which have the potential to transform the biopharmaceutical industry by enabling the targeting of currently inaccessible components of the proteome, are reviewed.
- Raymond J. Deshaies
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Spotlight |
Spotlight on the Netherlands
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Letter |
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of providing post-exposure therapeutic protection against lethal disease in 100% of drug-treated nonhuman primates infected with Ebola virus; the drug targets viral RNA polymerase and can distribute to sanctuary sites (such as testes, eyes and brain), suggesting that it may be able to clear persistent virus infection.
- Travis K. Warren
- , Robert Jordan
- & Sina Bavari
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Letter |
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure.
- Travis K. Warren
- , Jay Wells
- & Sina Bavari
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News |
Indian generics giants set sights on Japan
Country's drug industry looks to exploit growing Japanese market while fending off tougher European patents.
- Priya Shetty