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Open Access
Featured
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Chromosomal alterations among age-related haematopoietic clones in Japan
Population-specific patterns of genomic mutations and selection of haematopoietic clones in Japanese and European participants predict the divergent rates of chronic lymphocytic leukaemia and T cell leukaemia in these populations.
- Chikashi Terao
- , Akari Suzuki
- & Yoichiro Kamatani
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Brief Communications Arising |
Role of stem-cell divisions in cancer risk
- Cristian Tomasetti
- , Rick Durrett
- & Bert Vogelstein
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Article |
Substantial contribution of extrinsic risk factors to cancer development
Recent analyses have suggested that the intrinsic behaviour of tissue stem cells may be responsible for malignant transformation and cancer progression, raising questions regarding the influence of extrinsic factors on tumourigenesis; here, both data-driven and model-driven evidence show that such intrinsic risk factors contribute only marginally to cancer development, indicating that cancer risk is heavily influenced by extrinsic factors.
- Song Wu
- , Scott Powers
- & Yusuf A. Hannun
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Outlook |
Statistics: Attacking an epidemic
Despite a huge amount of funding and research, regional and individual differences in cancer trends make it a hard disease to wipe out. By Mike May.
- Mike May
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Outlook |
Prevention: Air of danger
Carcinogens are all around us, so scientists are broadening their ideas of environmental risk.
- Rebecca Kessler
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Outlook |
Developing world: Global warning
Much of the world is ill-equipped to cope with its rising cancer burden and are pushing prevention and screening.
- Eric Bender
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Outlook |
Drug development: Target practice
Better designs for clinical trials and the use of combination therapies may improve leukaemia treatment.
- Alla Katsnelson
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Outlook |
The hard facts
For women worldwide, breast cancer is the most common cancer diagnosed and has the highest death toll. With improvements in screening and treatments over the past 50 years, more women are living longer, but the numbers reveal some tough challenges. By Amy Maxmen.
- Amy Maxmen
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Outlook |
Exercise: Powering up
Physical activity has numerous proven benefits, and its long-contested ability to keep cancer at bay is now being put to the test.
- Julie Corliss
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News |
US environment agency misses dioxin deadline
Academia and industry unite to criticize delays in publishing regulatory guidelines.
- Brendan Borrell
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Editorial |
Asbestos scandal
Irresponsible policies could cause an epidemic of malignant lung disease.
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News Feature |
Epidemiology: Fear in the dust
Cancer epidemics in Turkey could hold the secret to staving off a public health disaster in North Dakota.
- Brendan Maher