This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tomasetti, C. & Vogelstein, B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015)
Tomasetti, C. & Vogelstein, B. Musings on the theory that variation in cancer risk among tissues is explained by the number of divisions of the normal stem cells. Preprint at https://arxiv.org/abs/1501.05035 (2015)
Tomasetti, C. & Vogelstein, B. Cancer risk: role of environment—response. Science 347, 729–731 (2015)
Wu, S ., Powers, S ., Zhu, W. & Hannun, Y. A. Substantial contribution of extrinsic risk factors to cancer development. Nature 529, 43–47 (2016)
Lansdorp-Vogelaar, I. et al. Contribution of screening and survival differences to racial disparities in colorectal cancer rates. Cancer Epidemiol. Biomarkers Prev. 21, 728–736 (2012)
Davies, L. & Welch, H. G. Increasing incidence of thyroid cancer in the United States, 1973-2002. J. Am. Med. Assoc. 295, 2164–2167 (2006)
Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010)
Greiner, T. C., Medeiros, L. J. & Jaffe, E. S. Non-Hodgkin’s lymphoma. Cancer 75 (Suppl.), 370–380 (1995)
Kort, E. J., Paneth, N. & Vande Woude, G. F. The decline in U.S. cancer mortality in people born since 1925. Cancer Res. 69, 6500–6505 (2009)
Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415–421 (2013)
Author information
Authors and Affiliations
Contributions
C.T. and B.V. conceived and designed the research. C.T., R.D., M.K., A.L., G.P., A.Z. and B.V. performed related research. C.T. and B.V. wrote the first draft of the article and all authors contributed to the submitted version.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Tomasetti, C., Durrett, R., Kimmel, M. et al. Role of stem-cell divisions in cancer risk. Nature 548, E13–E14 (2017). https://doi.org/10.1038/nature23302
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature23302
This article is cited by
-
Evaluating cancer etiology and risk with a mathematical model of tumor evolution
Nature Communications (2022)
-
Checkpoint functions of RecQ helicases at perturbed DNA replication fork
Current Genetics (2021)
-
Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
Scientific Reports (2020)
-
The location of premalignant colorectal polyps under age 50: a further rationale for screening sigmoidoscopy
International Journal of Colorectal Disease (2020)
-
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces
International Journal of Oral Science (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.