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Results generated with the use of microarrays should be properly described and deposited in one of the public databases prior to review. We examine the last two years of the journal's publications in an attempt to ensure that community standards for data deposition are met.
Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.
Common genomic structural variants predispose to deleterious de novo genomic rearrangements. Understanding how they do so will require population studies across the continuum of genomic variation and ethical discussion of the nature and uses of human variation.