Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
An unbiased approach for the genome-wide detection of off-target cleavage by CRISPR-Cas9 RNA–guided nucleases reveals wide variability in the off-target activity of different guide RNAs.
Combining four years of field data with computer modeling reveals that development of resistance to Bacillus thuringiensis insecticidal proteins (Bt) in cotton bollworm can be delayed by refuges of non-Bt host plants other than cotton, but that these so-called ‘natural refuges’ are not as effective as non-Bt cotton refuges.
A comprehensive analysis of RNA sequencing and single-nucleotide polymorphism (SNP) array data provides new insights into the biology of 675 human cancer cell lines
Results from the Oxford nanopore minION sequencer “early-release” program enable identification of the insertion site of an antibiotic resistance island in Salmonella Typhi.
Liu et al. provide new resources for improving rice by cloning a gene cluster that enhances resistance to two species of planthoppers, which cause billions of dollars of crop loss.
A comparison of different ways of generating induced pluripotent stem cells helps researchers choose the most appropriate method for particular applications.
An open competition to predict the progression of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) disease from the largest database of ALS clinical trial data yields potential new biomarkers and algorithms that outperform human clinicians.
Methylase-assisted bisulfite sequencing allows to determine the genomic locations of the cytosine demethylation intermediates 5-formylcytosine and 5-carboxylcytosine at base pair resolution.