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Insulin-like growth factor signalling encompasses a highly conserved system of ligands, receptors, and binding proteins that impact somatic growth by regulating cellular growth, differentiation, and survival. This system also plays a crucial role in carbohydrate metabolism, stem cell maintenance, and aging. Growing evidence also points to the involvement of these signaling pathways in cancer progression.
This Collection welcomes original research on all aspects of insulin-like growth factor signalling, from structural chemistry through cell biology and clinical medicine.