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Data availability
Datasets generated from this study are available on the Sequencing Reads Archive (https://www.ncbi.nlm.nih.gov/sra) using the following accession number: PRJNA998386.
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Acknowledgements
This work was supported by the Intramural Research Program of the National Heart, Lung, and Blood Institute and grants from the National Institutes of Health/National Cancer Institute (P01 CA225618, P30 CA06973). Sequencing was performed at the DNA Sequencing and Genomics core. The Center for Cancer Research Genomics core provided support for digital droplet PCR experiments.
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NR designed the study, conducted the research, analyzed and interpreted the results, and wrote the manuscript. LWD designed the study, conducted the research, analyzed, and interpreted the results. GG performed the statistical analysis for outcomes. MS, LPG, and RJJ collected samples and clinical data and provided clinical input. AC aided in the design and interpretation of droplet digital PCR experiments. AJA and CSH conceived and designed the study, collected samples, reviewed the results, and provided clinical input. All authors reviewed and approved the final manuscript.
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The National Heart, Lung, and Blood Institute receives research funding for the laboratory of CSH from the Foundation of the NIH AML MRD Biomarkers Consortium. AC is an employee and shareholder in Bio-Rad Laboratories. All other authors report no relevant conflict of interest.
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Ravindra, N., Dillon, L.W., Gui, G. et al. Persistent IDH mutations are not associated with increased relapse or death in patients with IDH-mutated acute myeloid leukemia undergoing allogeneic hematopoietic cell transplant with post-transplant cyclophosphamide. Bone Marrow Transplant 59, 428–430 (2024). https://doi.org/10.1038/s41409-023-02189-9
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DOI: https://doi.org/10.1038/s41409-023-02189-9