Constraining conformation
Peptide stapling improves stability and enhances binding. Non-symmetric stapling greatly expands the applicability of the approach, but introduces challenges of chemoselectivity and site-selectivity.
Peptide stapling improves stability and enhances binding. Non-symmetric stapling greatly expands the applicability of the approach, but introduces challenges of chemoselectivity and site-selectivity.
The synthesis of thermodynamically disfavoured substituted six-membered rings provides a notable challenge compared with that of the thermodynamically stable stereoisomer counterparts. This Review provides a summary of current strategies for their synthesis.