Volume 630 Issue 8015, 6 June 2024

Automated approaches to translation could provide a lifeline to under-resourced languages, but only if companies engage with the people who speak them.

Governments must act now on vaccine and pathogen-sample sharing, or any agreement will be a promise only on paper.

The little bush moa had small eyes, no wings and some extraordinary skills.

The emotional load of listening to one’s own performance is preserved by a certain type of sleep.

Satellite data help to show that many people with access to electricity cannot take advantage of it.

Two species in the gut microbiome transform corticosteroids into progestins, which can affect mood and behaviour.

People treated with gene therapy cannot receive a second dose for fear of a dangerous immune response. Researchers hope to find a way around this.

Researchers are aiming to create fully accessible versions of the latest iteration of DeepMind’s blockbuster protein-structure model.

Semaglutide, the same compound in obesity drug Wegovy, slashes risk of kidney failure and death for people with diabetes.

Bacterial defensive systems scramble the standard workflow of life.

The transplant aims to prolong the the person’s life and provides important lessons for physicians.

Two particular broods of the insects are popping up together for the first time in two centuries, and there’s a lot we don’t know about them.

Chemists achieve synthetic feat with radioactive promethium for the first time.

The melding of artificial intelligence and robotics could catapult both fields to new heights.

Simulated lunar exploration in an Arizona volcanic field this month helped astronauts to prepare for doing geology in harsh conditions at the lunar south pole. Nature joined mission control.

In today’s polarized political climate, researchers who combat mistruths have come under attack and been labelled as unelected arbiters of truth. But the fight against misinformation is valid, warranted and urgently required.

A sample of roughly two million WhatsApp messages highlights urgent concerns about the spread and prevalence of AI-generated political content.

Although researchers often face uncertainty when grants expire with no replacement in sight, there are creative ways to ease the dry spell.

Fluorescent labels that have greater resistance to bleaching could help researchers to get more from biological imaging.

Over the past 25 years, Kristine Ulvund has helped to increase the species’ population size from 50 or so individuals to more than 500.

Soft solids that swell with shifts in pressure, temperature and pH provide a way of detecting such changes in the fluid around the brain. The method could be used to determine other properties of fluids elsewhere in the body.

Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal.

A simple design approach and predictive computational methods have spawned a pathway for making materials that could trap specific molecules — an ability needed for applications such as carbon capture.

When chromosomes are lost or gained, massive changes in gene expression disrupt the delicate balance of proteins in a cell. Yeasts with incorrect chromosome numbers counteract this by degrading excess proteins.

Uptake of ammonium ions by marine microorganisms called archaea is a key first step in the conversion of ammonium to nitrogen found in ecosystems. Structural evidence reveals how archaea capture ammonium in an efficient way.

This Perspective identifies common misperceptions regarding the harms of online misinformation, finding that exposure to false and inflammatory content is rare and concentrated among a small minority of people who already have extreme views.

JWST observations of a massive galaxy at a redshift of 2.45 show a powerful outflow of neutral gas, with a mass outflow rate that is sufficient to shut down star formation.

An approach called wavefunction matching transforms particle interactions so that their wavefunctions match those of easily computable interactions, to allow for calculations of quantum many-body systems that would otherwise be difficult or impossible.

We observe the superconducting diode effect and interference patterns in CsV₃Sb₅, implying a time-reversal symmetry-breaking superconducting order in kagome superconductors.

A modular quantum system-on-chip architecture integrates thousands of individually addressable spin qubits in two-dimensional quantum microchiplet arrays into an integrated circuit designed for cryogenic control, supporting full connectivity for quantum memory arrays across spin–photon channels.

By combining spatial and frequency dispersive thin-film interfaces with deep residual learning, a miniature photodetector allowing the acquisition of high-dimensional information on light in a single-shot fashion is described.

A bioresorbable, wireless hydrogel (metagel) sensor, encompassing both biodegradable and stimulus-responsive hydrogels for ultrasonic monitoring of intracranial signals, was implanted into intracranial space with a puncture needle and deformed in response to physiological environmental changes.

Microballistic impact testing at strain rates greater than 10⁶ s⁻¹ shows that pure metals, including copper, gold and titanium, become stronger with increasing temperature.

A previously undescribed photocatalytic approach enables the effective p-type and n-type doping of organic semiconductors at room temperature using only widely available weak dopants such as oxygen and triethylamine.

The use of computational crystal-structure prediction has enabled the targeted assembly of frameworks of porous organic ammonium halide salts that have many of the qualities of metal–organic frameworks despite containing no metal.

Time-resolved photoelectron circular dichroism with a temporal resolution of 2.9 fs is used to track the ultrafast electron dynamics following ultraviolet excitation of neutral chiral molecules, which generate chiral currents that exhibit periodic rotation direction reversal.

We analyse cell division in ichthyosporeans and find that multinucleated life cycles favour the evolution of closed mitosis, in which the cell constructs a spindle within an intact nucleus.

Many companies unknowingly advertise on websites that publish misinformation despite the reputational and financial risks, and increased transparency for consumers and advertisers could counter unintended ad revenue going to misinformation websites.

Difference-in-differences analysis indicates that the decision by Twitter to deplatform 70,000 users following the events at the US Capitol on 6 January 2021 had wider effects on the spread of misinformation.

Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifying the circuits that lead to opioid addiction.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

Harnessing single-nucleus RNA sequencing and spatial profiling, this work dissects unanticipated aspects of human liver regeneration to uncover a novel migratory hepatocyte subpopulation mediating wound closure following acute liver injury.

Single-cell RNA sequencing and 3D imaging have revealed the cellular changes and structural reorganization that occur during the progression of human chronic liver disease and as the liver attempts to regenerate.

The transcription factor Myb-M is the earliest determinant of male fate in the parasite Cryptosporidium parvum.

Prov-GigaPath, a whole-slide pathology foundation model pretrained on a large dataset containing around 1.3 billion pathology images, attains state-of-the-art performance in cancer classification and pathomics tasks.

Experiments in mouse models, and in cell lines that only allow primary Vκ-to-Jκ rearrangements, enable characterization of the mechanisms of V(D)J recombination.

Using a multimodal approach across acute leukaemias, a targetable PI3Kγ dependency in leukaemias is explored.

Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.

A distinct cell cycle redeploys many canonical cell cycle regulators to control the differentiation of multiciliated cells, with the transcription factor E2F7 playing a pivotal part in this modified cell cycle.

The assembly of the γδ TCR depends on Vγ usage.

The Nitrosopumilus maritimus surface layer (S-layer) concentrates ammonium ions on its cell-facing side, acting as a multichannel sieve on the cell membrane.

Detailed analyses of the serotonin receptor 5-HT_1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.

Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.