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World’s biggest set of human genome sequences opens to scientists

The whole genomes of 500,000 people in the UK Biobank will help researchers to probe our genetic code for links to disease.


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  • A plasma set-up consisting of a pair of carbon-fibre-tip-enhanced electrodes enables the generation of a uniform, ultra-high temperature and stable plasma (up to 8,000  K) at atmospheric pressure using a combination of vertically oriented long and short carbon fibres.

    • Hua Xie
    • Ning Liu
    • Liangbing Hu
  • After loss of MSL2, a class of dosage-sensitive genes transitions from biallelic to monoallelic expression, whereby one allele remains active, retaining active histone modifications and transcription factor binding, and the other allele is silenced, exhibiting loss of promoter–enhancer contacts and the acquisition of DNA methylation.

    • Yidan Sun
    • Meike Wiese
    • Asifa Akhtar
    ArticleOpen Access
  • An autonomous laboratory, the A-Lab, is presented that combines computations, literature data, machine learning and active learning, which discovered and synthesized 41 novel compounds from a set of 58 targets after 17 days of operation.

    • Nathan J. Szymanski
    • Bernardus Rendy
    • Gerbrand Ceder
    ArticleOpen Access
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Institutions in major cities can play a crucial role in helping rural areas build resilience in the face of climate change and other global challenges.
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