Review Article |
Featured
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Review Article |
The potential of mitochondrial genome engineering
The authors review the field of mammalian mitochondrial genome engineering, culminating in the recent development of mitochondrially targeted programmable nucleases and base editors. They describe research that led to the development of animal models of mitochondrial disease, as well as the potential for translating these approaches to the clinic.
- Pedro Silva-Pinheiro
- & Michal Minczuk
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Review Article |
Advancing the use of genome-wide association studies for drug repurposing
Genome-wide association studies (GWAS) have revealed important biological insights into complex diseases. The authors review approaches that leverage GWAS to identify opportunities for repurposing existing drugs, including single-loci mapping to drug targets, transcriptome-wide association studies, gene-set association, causal inference by Mendelian randomization and polygenic scoring.
- William R. Reay
- & Murray J. Cairns
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Review Article |
Theranostic cells: emerging clinical applications of synthetic biology
Synthetic biology has enabled the development of engineered cells that can serve as ex vivo or in vivo diagnostic tools or therapeutic delivery systems. This Review discusses preclinical and clinical applications of bacterial and mammalian theranostic cells as well as their underlying biological designs and remaining hurdles to their successful clinical application.
- Monica P. McNerney
- , Kailyn E. Doiron
- & Pamela A. Silver
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Comment |
Going to the negative: genomics for optimized medical prescription
In personalized medicine, a major aim is to provide the right treatment to the right patient. In this Comment article, Gibson discusses how a more overt and genomics-informed focus on those individuals who are unlikely to benefit from treatment could reduce prescription rates and provide financial and health-care benefits.
- Greg Gibson
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Review Article |
Transplant genetics and genomics
Advances in genetics and genomics have transformed the field of organ transplantation. Here, the authors review the role of genetic dissimilarities between donor and recipient in transplant tolerance and rejection, and how the identification of genetic variants that predict adverse transplant outcomes can be used for personalized medicine.
- Joshua Y. C. Yang
- & Minnie M. Sarwal
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Review Article |
The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts
The authors discuss the evolutionary dynamics of antibiotic resistance in bacteria in relation to the complex interplay between population genetic factors and the spatial and temporal pattern of antibiotic use.
- R. Craig MacLean
- , Alex R. Hall
- & Angus Buckling
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