Risk factors articles within Nature Reviews Genetics

Featured

  • Review Article |

    Despite the success of human genome-wide association studies (GWAS) in associating genetic variants and complex diseases or traits, criticisms of the usefulness of this study design remain. This Review assesses the pros and cons of GWAS, with a focus on the cardiometabolic field.

    • Vivian Tam
    • , Nikunj Patel
    •  & David Meyre

  • Review Article |

    Common diseases have complex aetiology involving the interplay of genetic susceptibility and environmental risk factors. Here, the authors describe methods for building and evaluating models for the prediction of disease risk based on information from genetic testing and environmental factors, and use case studies to illustrate the potential of such models in the prevention of diseases.

    • Nilanjan Chatterjee
    • , Jianxin Shi
    •  & Montserrat García-Closas

  • Analysis |

    There are various measures to quantify the contribution of genetic variants to disease risk, but differing terminology and assumptions obfuscate their use and interpretation. In this Analysis, the authors consider and contrast six commonly used measures that assess disease risk of individual variants, and provide numerical examples in breast cancer, Crohn's disease, rheumatoid arthritis and schizophrenia.

    • John S. Witte
    • , Peter M. Visscher
    •  & Naomi R. Wray

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