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Neuronal physiology refers to the biology of neuronal function, including an understanding of the molecular and cellular processes that underlie neuronal activity.
Voltage-Seq is a method for all-optical voltage imaging-guided postsynaptic single-cell transcriptomics. It combines the use of the Voltron voltage indicator with the analysis tool VoltView to select specific neuronal somas to collect for single-cell RNA sequencing.
Conjugation of self-labeling enzymatic tags to axonal membrane proteins enables studying the dynamics of their trafficking, cellular localization and fate.
How each mechanism of plasticity contributes to memory formation is not fully understood. Here the authors show that plasticity of intrinsic excitability exerts permissive control over the coupling of synaptic weight to neuronal output, as shown in Purkinje cells using two-photon microscopy. Non-synaptic plasticity emerges as an independent player in learning.
LINE-1 retrotransposons are a type of mobile DNA element normally repressed in the body. Here the authors show that LINE-1 sequences can jump in mouse parvalbumin interneurons and also promote the transcription of key parvalbumin interneuron genes.
The mechanisms underlying the zebrafish spinal cord’s impressive innate ability to regenerate after traumatic insults remain largely unknown. Here, the authors show that spinal neurons enact an essential neuron-to-neuron neuroprotective strategy to safeguard cell survival and support the zebrafish’s regeneration process.
A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS) and shows a role for contactin-1 in assembly of the AIS extracellular matrix.