Research Highlight |
Featured
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Progress |
Heart failure: advances through genomics
Genetic and genomic approaches — including high-throughput sequence analysis and transcriptomics experiments — are revealing a clearer picture of the pathophysiological steps underlying the different forms of heart failure (genetic and acquired) and the genomic responses to cardiac overload.
- Esther E. Creemers
- , Arthur A. Wilde
- & Yigal M. Pinto
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From The Editors |
From the editors
Highlights from the world of stem cells in a special Focus issue.
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Correspondence |
Tests of association for rare variants: case control mutation screening
- Sean V. Tavtigian
- , Mia Hashibe
- & Alun Thomas
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Correspondence |
Missing heritability: paternal age effect mutations and selfish spermatogonia
- Anne Goriely
- & Andrew O. M. Wilkie
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Review Article |
The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts
The authors discuss the evolutionary dynamics of antibiotic resistance in bacteria in relation to the complex interplay between population genetic factors and the spatial and temporal pattern of antibiotic use.
- R. Craig MacLean
- , Alex R. Hall
- & Angus Buckling
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An Interview With... |
Shinya Yamanaka
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From The Editors |
From the editors
Towards models of disease pathogenesis from diverse genetic causes.
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Comment |
Accelerate medical breakthroughs by ending disease earmarks
A shift towards studying connections between diseases will be essential to accelerate the translation of biomedical research.
- Sharon F. Terry
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Review Article |
Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait
Retinal degeneration due to photoreceptor cell death is a major cause of visual impairment in adults. Over one hundred genes have been implicated, so how does this genetic heterogeneity converge on a shared phenotype? The emerging insights have implications for therapy.
- Alan F. Wright
- , Christina F. Chakarova
- & Shomi S. Bhattacharya
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Review Article |
Repeat expansion disease: progress and puzzles in disease pathogenesis
Expansions of repeat sequences cause some of the most common inherited neurological diseases. But how do repeats in DNA lead to pathogenesis? This Review considers the diverse mechanisms that are now emerging, including aberrant splicing, post-translational modification and autophagy.
- Albert R. La Spada
- & J. Paul Taylor
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